Research: Aging Network Bioinformatics
The experiment
Previously I ran an experiment to find central genes from the OSK genes used to create induced pluripotent stem cells to the global aging genes (genes discovered in a paper by checking many aging tissues and seeing what genes are either up or down regulated in common across the different tissues). Now my question is, what are the genes central to the global aging genes? Does it link to the aging machinery that governs the cell?
So what we’ll do to find the central genes is compare the global aging genes to themselves in a pairwise fashion. To be more precise, it’ll be like having two lists of all the global aging genes and we’ll compare every pair between the two lists. When we compare the pairs, we’ll find the strongest path of interactions through the gene regulatory network. Then we aggregate these strongest paths by counting the nodes that appear over and over again.
The experiment is run on the global aging genes while the control is run on randomly selected genes from the regulatory network.
The data
The network is downloaded from https://downloads.thebiogrid.org/File/BioGRID/Release-Archive/BIOGRID-5.0.255/BIOGRID-ORGANISM-5.0.255.tab3.zip it uses the mus musculus file for lab mice. Note there are genes in biogrid that aren’t found in gene_info like 6622 is only found for humans.
The way I converted between Entrez ids and actual gene names I used https://www.ncbi.nlm.nih.gov/books/NBK3840/?utm_source=chatgpt.com#:~:text=You%20can%20therefore%20convert%20any%20GeneID%20into%20its%20current%20names%20by%20using%20the%20definitions%20provided%20in%20the%20file%20available%20as%20https%3A//ftp.ncbi.nlm.nih.gov/gene/DATA/gene_info.gz Note there are symbols collisions, the synonyms for a gene can be the same for multiple genes.
I used the mouse global aging gene (GAG) data from this paper https://elifesciences.org/articles/62293 and the direct link to the data is here https://figshare.com/articles/dataset/tms_gene_data_rv1/12827615?file=27857814.
Finally I used the GenAge dataset that is a dataset of genes related to aging https://genomics.senescence.info/download.html.
The code
The code can be found here: https://github.com/luojxxx/Aging-machinery. The dependencies are all at the top.
The code itself is relatively simple. It loads and cleans all the data. Importing the biogrid network as an undirected graph and finding the shortest path between the target genes.
The experiment compares the GAG list to itself. While the control takes the regulatory pathway and samples randomly from the 19299 genes in the biogrid dataset. There’s the same number of random genes as the global aging genes (324 genes), so that it’s comparable.
If you want to run it yourself, just put the ipython notebook, gene_info dataset, biogrid dataset, GAG dataset, and GenAge dataset in the same folder.
The results
The results are promising. Although the experimental results are enriched less so than the control results, you can tell by the path length histograms it’s just because the paths are much more direct in the experimental group than the control group. The overlapping genes between the experimental and control group does show that the enrichment favors the control group, but that it just because of the point made earlier with shorter paths. There’s also a full third of the experimental results are not overlapping at all with the random control group which suggest better separation between experimental and random results. Overall, this could point to a central mechanism to aging that merits additional research.
Experimental Results
Size: 1758
Average: 76.65642775881683
Median: 7.0
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27966: 2, 17974: 2, 11431: 2, 17758: 2, 192159: 2, 10987: 2, 112407: 2, 18771: 2, 23592: 2, 53376: 2, 53417: 2, 114606: 2, 214384: 2, 904: 2, 98660: 2, 17248: 2, 21349: 2, 68652: 2, 26409: 2, 4731: 2, 209318: 2, 12929: 2, 54644: 2, 19691: 2, 99730: 2, 17684: 2, 71242: 2, 231580: 2, 229615: 2, 69726: 2, 105245: 2, 26417: 2, 12419: 2, 235442: 2, 83767: 2, 97387: 2, 27373: 2, 18163: 2, 107650: 2, 545389: 2, 219158: 2, 15903: 2, 233870: 2, 17257: 2, 72459: 2, 26414: 2, 21417: 2, 30953: 2, 20660: 2, 13819: 2, 20655: 2, 20613: 2, 642: 2, 1785: 2, 5192: 2, 27333: 2, 821: 2, 8402: 2, 11877: 2, 8662: 2, 51008: 2, 11231: 2, 14228: 2, 54815: 2, 71241: 2, 1996: 2, 51626: 2, 57181: 2, 66335: 2, 211006: 2, 101568: 2, 100040551: 2, 13824: 2, 20103: 2, 13858: 2, 14852: 2, 22160: 2, 56312: 2, 74370: 2, 67040: 2, 13209: 2, 26562: 2, 104001: 2, 103967: 2, 81702: 2, 18212: 2, 56299: 2, 15163: 2, 415115: 2, 19697: 2, 14725: 2, 13806: 2, 12896: 2, 20917: 2, 12268: 2, 14645: 2, 15434: 2, 19896: 2, 52892: 2, 71946: 2, 226778: 2, 7126: 2, 67804: 2, 20277: 2, 12568: 2, 66420: 2, 66830: 2, 19345: 2, 97122: 2, 16682: 2, 64136: 2, 59125: 2, 54138: 2, 68045: 2, 17254: 2, 67089: 2, 74126: 2, 21834: 2, 72354: 2, 13542: 2, 20935: 2, 100044627: 2, 18451: 2, 12464: 2, 17356: 2, 9619: 2, 10179: 2, 54433: 2, 66700: 2, 85464: 2, 140486: 2, 83431: 2, 11625: 2, 233071: 2, 110842: 2, 1778: 2, 989: 2, 19712: 2, 1936: 2, 14571: 2, 228998: 2, 66447: 2, 20230: 2, 58208: 2, 26558: 2, 7341: 2, 4627: 2, 226562: 2, 20021: 2, 320024: 2, 5888: 2, 53612: 2, 22288: 2, 20524: 2, 232807: 2, 110253: 2, 102866: 2, 10121: 2, 22185: 2, 13548: 2, 12696: 2, 18107: 2, 192193: 2, 19089: 2, 12028: 2, 20589: 2, 11447: 2, 214498: 2, 16828: 2, 19385: 2, 27494: 2, 223593: 2, 12467: 2, 28000: 2, 21847: 2, 224824: 2, 17129: 2, 55994: 2, 14463: 2, 19650: 2, 243833: 2, 215821: 2, 11957: 2, 57423: 2, 66419: 2, 20853: 2, 13017: 2, 65970: 2, 67025: 2, 20512: 2, 21399: 2, 20615: 2, 232975: 2, 208117: 2, 20671: 2, 74192: 2, 21985: 2, 22327: 2, 22352: 2, 11852: 2, 68365: 2, 57296: 2, 11804: 2, 22317: 2, 56085: 2, 70790: 2, 16542: 2, 53611: 2, 108664: 2, 13010: 2, 20907: 2, 67615: 2, 11772: 2, 11807: 2, 66881: 2, 13855: 2, 19231: 2, 16975: 2, 18453: 2, 20194: 2, 5493: 2, 20195: 2, 79709: 2, 5351: 2, 16952: 2, 22193: 2, 107995: 2, 16451: 2, 67673: 2, 59272: 2, 16647: 2, 22200: 2, 225870: 2, 72341: 2, 116986: 2, 12325: 2, 21856: 2, 216825: 2, 234594: 2, 231532: 2, 66724: 2, 20473: 2, 15403: 2, 24113: 2, 70779: 2, 18505: 2, 12023: 2, 20019: 2, 80838: 2, 5071: 2, 7316: 2, 21351: 2, 12340: 2, 11737: 2, 16854: 2, 231003: 2, 4144: 2, 50873: 2, 1213: 2, 235339: 2, 18642: 2, 22138: 2, 16498: 1, 13805: 1, 9897: 1, 8073: 1, 16019: 1, 11928: 1, 19179: 1, 24148: 1, 66194: 1, 18813: 1, 12576: 1, 170791: 1, 69091: 1, 57410: 1, 5962: 1, 3842: 1, 6747: 1, 26092: 1, 8666: 1, 7458: 1, 22818: 1, 23607: 1, 79026: 1, 56440: 1, 21929: 1, 24055: 1, 17060: 1, 13690: 1, 210293: 1, 269587: 1, 52637: 1, 100502698: 1, 227753: 1, 51081: 1, 4007: 1, 908: 1, 19744: 1, 99152: 1, 97165: 1, 63958: 1, 234267: 1, 155459: 1, 73086: 1, 65019: 1, 94190: 1, 108911: 1, 14158: 1, 433926: 1, 80708: 1, 76742: 1, 66237: 1, 233871: 1, 71978: 1, 19290: 1, 10492: 1, 9185: 1, 282323: 1, 69253: 1, 59287: 1, 15191: 1, 23196: 1, 10907: 1, 19652: 1, 13685: 1, 14104: 1, 72330: 1, 13822: 1, 21416: 1, 3192: 1, 8454: 1, 30841: 1, 108679: 1, 68202: 1, 70312: 1, 235604: 1, 19942: 1, 18571: 1, 99412: 1, 15185: 1, 218693: 1, 229949: 1, 15452: 1, 19173: 1, 23950: 1, 83945: 1, 229663: 1, 14791: 1, 22166: 1, 14457: 1, 28006: 1, 106039: 1, 27316: 1, 56541: 1, 4868: 1, 19417: 1, 10273: 1, 66945: 1, 235072: 1, 68267: 1, 66144: 1, 114774: 1, 12322: 1, 66108: 1, 319504: 1, 18472: 1, 11430: 1, 11980: 1, 78920: 1, 20965: 1, 5710: 1, 17380: 1}
Histogram of the path lengths for experimental counts
Control Results
Size: 3177
Average: 93.68649669499528
Median: 10
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476, 21402: 472, 433759: 467, 66131: 467, 68581: 467, 19211: 464, 99982: 457, 75608: 455, 6622: 454, 56086: 453, 320299: 453, 3028: 452, 224997: 450, 23834: 450, 12847: 449, 56455: 444, 11690: 440, 23983: 434, 17966: 424, 26934: 423, 18412: 420, 13433: 419, 227613: 415, 51792: 413, 20430: 413, 27221: 413, 26409: 412, 12166: 409, 17984: 406, 12266: 400, 16531: 400, 19173: 396, 328572: 390, 170762: 389, 801: 387, 11739: 387, 75770: 385, 67809: 383, 12566: 382, 665113: 382, 5879: 382, 116870: 378, 59026: 376, 20403: 375, 16709: 373, 20924: 373, 56637: 371, 17187: 371, 13018: 370, 66661: 368, 11772: 366, 54726: 365, 67465: 360, 11820: 358, 23942: 357, 94186: 357, 74764: 347, 65113: 345, 12824: 345, 17126: 343, 899: 341, 209446: 339, 15526: 339, 13383: 337, 13191: 337, 403183: 336, 18140: 336, 17345: 331, 12125: 329, 17217: 326, 16477: 326, 240057: 323, 23790: 322, 29810: 322, 12826: 321, 12387: 319, 108800: 319, 76117: 319, 20068: 318, 18022: 310, 56480: 308, 214137: 307, 67731: 305, 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60, 12370: 60, 8085: 60, 66591: 60, 21812: 60, 6134: 60, 1620: 59, 268932: 59, 6453: 59, 1975: 59, 983: 59, 211922: 59, 320271: 59, 20614: 58, 11946: 58, 14463: 58, 8878: 58, 22632: 57, 103733: 57, 12540: 57, 5888: 57, 16179: 57, 100090: 57, 6187: 57, 22003: 56, 67115: 56, 13628: 56, 13990: 56, 20479: 56, 1454: 56, 15505: 56, 66413: 56, 78610: 56, 6118: 56, 52615: 55, 11840: 55, 14688: 55, 5499: 55, 66375: 55, 19185: 54, 1315: 54, 13728: 54, 1639: 54, 22151: 54, 5903: 54, 20185: 54, 13858: 54, 10015: 53, 904: 53, 16648: 53, 12340: 53, 22938: 52, 10616: 52, 57765: 52, 22350: 52, 69719: 52, 12848: 52, 18518: 52, 24654: 52, 60488: 51, 11080: 51, 66440: 51, 74148: 51, 54609: 51, 208263: 50, 110809: 50, 1186: 50, 9961: 49, 13494: 49, 11928: 49, 240641: 49, 97212: 49, 54126: 49, 22334: 49, 19205: 49, 891: 49, 26362: 48, 75964: 48, 20965: 48, 68549: 48, 11669: 48, 17992: 48, 93765: 48, 70834: 48, 12703: 48, 50850: 48, 6128: 47, 239528: 47, 19339: 47, 21856: 47, 20174: 47, 18764: 47, 523: 47, 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19344: 4, 12010: 4, 14679: 4, 17261: 4, 13198: 4, 18797: 4, 11496: 4, 104082: 4, 269582: 4, 67118: 4, 16576: 4, 269774: 4, 12995: 4, 11867: 4, 230753: 4, 239796: 4, 20351: 4, 23435: 4, 6632: 4, 148423: 4, 218693: 4, 18951: 4, 19299: 4, 70584: 4, 14183: 4, 17179: 4, 14388: 4, 2885: 4, 25843: 4, 79073: 4, 18130: 4, 5518: 4, 22330: 4, 69601: 4, 219: 4, 71241: 4, 216190: 4, 18571: 4, 10049: 4, 79915: 4, 15519: 4, 10096: 4, 54888: 4, 433702: 4, 66734: 4, 155459: 4, 13688: 4, 9978: 4, 230904: 4, 5576: 4, 269610: 4, 207165: 4, 54566: 4, 74187: 4, 23164: 4, 18127: 4, 20646: 4, 71999: 4, 19261: 4, 830: 4, 81608: 4, 22803: 4, 68196: 4, 234366: 4, 27979: 4, 192111: 4, 64933: 4, 14450: 4, 20624: 4, 11431: 4, 72124: 4, 30838: 4, 5170: 4, 55527: 4, 10801: 4, 5139: 4, 23224: 4, 23191: 4, 4710: 4, 21416: 4, 59007: 4, 19651: 4, 76900: 4, 3646: 4, 18453: 4, 5394: 4, 5646: 4, 5932: 4, 132430: 4, 2778: 4, 232339: 4, 5094: 4, 5595: 4, 6229: 4, 79456: 4, 105859: 4, 28973: 4, 216799: 4, 70405: 4, 7384: 4, 381813: 4, 66945: 4, 56451: 4, 238988: 4, 20724: 4, 55949: 4, 2976: 4, 20084: 4, 3009: 4, 13518: 4, 109113: 4, 11143: 4, 8100: 4, 20650: 4, 9950: 4, 227693: 4, 1894: 4, 8826: 4, 55914: 4, 28987: 4, 2799: 4, 16364: 4, 16542: 4, 70675: 4, 67863: 4, 56381: 4, 234311: 4, 22123: 4, 66725: 4, 67951: 4, 67420: 4, 68147: 4, 231051: 4, 12709: 4, 51264: 4, 51493: 4, 26986: 4, 10848: 4, 118: 4, 64924: 4, 51692: 4, 105083: 4, 445007: 4, 671535: 4, 65111: 4, 224824: 4, 12633: 4, 58184: 4, 57753: 4, 74081: 4, 74196: 4, 224705: 4, 224111: 4, 208043: 4, 99730: 4, 54978: 4, 72590: 4, 5515: 4, 20336: 4, 55722: 4, 55785: 4, 9826: 4, 16332: 4, 11977: 4, 8239: 4, 9775: 4, 17113: 4, 1622: 4, 9500: 4, 319178: 4, 4926: 4, 56987: 4, 22992: 4, 5000: 4, 9767: 4, 20278: 3, 29864: 3, 110446: 3, 8454: 3, 68558: 3, 14228: 3, 5707: 3, 66576: 3, 19084: 3, 9349: 3, 13548: 3, 2746: 3, 74132: 3, 26557: 3, 80728: 3, 3482: 3, 94056: 3, 22210: 3, 26905: 3, 9055: 3, 53972: 3, 108098: 3, 68942: 3, 361274: 3, 23759: 3, 6204: 3, 76959: 3, 241274: 3, 19989: 3, 2975: 3, 235339: 3, 66988: 3, 20910: 3, 68267: 3, 9493: 3, 73710: 3, 22696: 3, 22720: 3, 29676: 3, 5982: 3, 71810: 3, 2934: 3, 129831: 3, 22042: 3, 51869: 3, 233071: 3, 219249: 3, 217207: 3, 14057: 3, 72993: 3, 23299: 3, 110651: 3, 57808: 3, 71228: 3, 67295: 3, 22820: 3, 20841: 3, 68193: 3, 9554: 3, 7343: 3, 66700: 3, 104721: 3, 12974: 3, 8899: 3, 52398: 3, 26451: 3, 103784: 3, 598: 3, 215351: 3, 19878: 3, 8930: 3, 56217: 3, 23894: 3, 106957: 3, 15268: 3, 20254: 2, 12391: 2, 73158: 2, 24131: 2, 4544: 2, 13206: 2, 16400: 2, 18645: 2, 11800: 2, 23885: 2, 51160: 2, 26425: 2, 3329: 2, 114034: 2, 3434: 2, 8602: 2, 19672: 2, 55706: 2, 79169: 2, 16691: 2, 24051: 2, 14783: 2, 66616: 2, 12334: 2, 12014: 2, 1523: 2, 5528: 2, 140629: 2, 6433: 2, 25836: 2, 7158: 2, 72333: 2, 131474: 2, 55700: 2, 12421: 2, 14161: 2, 114606: 2, 26918: 2, 21652: 2, 57741: 2, 110379: 2, 71679: 2, 67003: 2, 227197: 2, 6628: 2, 100503605: 2, 330662: 2, 26949: 2, 10294: 2, 10174: 2, 223254: 2, 6645: 2, 110784: 2, 11827: 2, 12053: 2, 20276: 2, 18008: 2, 196528: 2, 19280: 2, 110750: 2, 13804: 2, 19139: 2, 24144: 2, 100287932: 2, 19934: 2, 8574: 2, 7919: 2, 58996: 2, 268480: 2, 19134: 2, 72459: 2, 13435: 2, 19017: 2, 6124: 2, 93761: 2, 56177: 2, 18223: 2, 13859: 2, 23623: 2, 7385: 2, 64750: 2, 84128: 2, 14465: 2, 14173: 2, 80318: 2, 29015: 2, 5256: 2, 71752: 2, 11340: 2, 10200: 2, 5201: 2, 192159: 2, 12361: 2, 51362: 2, 22629: 2, 23094: 2, 20408: 2, 26148: 2, 3146: 2, 84298: 2, 15331: 2, 20909: 2, 16319: 2, 68626: 2, 207425: 2, 11737: 2, 55907: 2, 55692: 2, 68977: 2, 228714: 2, 26891: 2, 67186: 2, 140710: 2, 74192: 2, 211948: 2, 22682: 2, 19088: 2, 192662: 2, 27261: 2, 56717: 2, 15370: 2, 67393: 2, 23805: 2, 60: 2, 110920: 2, 229700: 2, 226646: 2, 107305: 2, 208846: 2, 1785: 2, 539: 2, 9867: 2, 232232: 2, 1762: 2, 8237: 2, 3673: 2, 3032: 2, 170791: 2, 75956: 2, 21892: 2, 320790: 2, 218490: 2, 56515: 2, 225745: 2, 54534: 2, 55975: 2, 11171: 2, 64708: 2, 21388: 2, 18484: 2, 66870: 2, 67039: 2, 76899: 2, 19025: 2, 11568: 2, 235606: 2, 21843: 2, 14236: 2, 13395: 2, 51759: 2, 14884: 2, 26961: 2, 56736: 2, 1107: 2, 231659: 2, 68507: 2, 238693: 2, 16681: 2, 72199: 2, 69116: 2, 69077: 2, 116940: 2, 16898: 2, 11865: 2, 16565: 2, 225020: 2, 7353: 2, 15114: 2, 226432: 2, 22393: 2, 14466: 2, 17760: 2, 106504: 2, 69684: 2, 19942: 2, 78757: 2, 22697: 2, 56716: 2, 60321: 2, 12866: 2, 19946: 2, 243621: 2, 28080: 2, 11595: 2, 228829: 2, 108841: 2, 56207: 2, 18040: 2, 11682: 2, 66556: 2, 234852: 2, 5566: 2, 23969: 2, 23499: 2, 12013: 2, 14106: 2, 319322: 2, 231225: 2, 67838: 2, 80744: 2, 18541: 2, 16777: 2, 71955: 2, 54617: 2, 23317: 2, 21804: 2, 71919: 2, 20262: 2, 445: 2, 74386: 2, 4172: 2, 29777: 2, 9147: 2, 26353: 2, 29115: 2, 76482: 2, 19691: 2, 16500: 2, 100288687: 2, 6711: 2, 7866: 2, 234214: 2, 12367: 2, 9101: 2, 3065: 2, 53356: 2, 16948: 2, 68089: 2, 17192: 2, 3024: 2, 19385: 2, 14645: 2, 21345: 2, 78038: 2, 319168: 2, 13808: 2, 235626: 2, 20643: 2, 67490: 2, 12380: 2, 16551: 2, 16423: 2, 53321: 2, 22671: 2, 11636: 2, 110891: 2, 50769: 2, 241275: 2, 12286: 2, 11877: 2, 16897: 2, 213990: 2, 58994: 2, 7874: 2, 65056: 2, 69504: 2, 27217: 2, 18012: 2, 5978: 2, 224170: 2, 52163: 2, 8697: 2, 8502: 2, 1613: 2, 8725: 2, 284119: 2, 26886: 2, 8933: 2, 284217: 2, 12042: 2, 70470: 2, 67268: 2, 21679: 2, 23291: 2, 6500: 2, 1655: 2, 6502: 2, 19885: 2, 6840: 2, 15482: 2, 8766: 2, 1666: 2, 54620: 2, 12444: 2, 7341: 2, 22218: 2, 30968: 2, 125988: 2, 7798: 2, 54887: 2, 51797: 2, 283489: 2, 71718: 2, 19186: 2, 67972: 2, 720: 2, 108664: 2, 53328: 2, 67511: 2, 77254: 2, 215821: 2, 17709: 2, 271457: 2, 230075: 2, 56215: 2, 20637: 2, 19099: 2, 67040: 2, 22152: 2, 51575: 2, 23598: 2, 4174: 2, 21770: 2, 13063: 2, 108888: 2, 12298: 2, 66373: 2, 14536: 2, 7316: 2, 14415: 2, 18549: 2, 6597: 2, 10212: 2, 19042: 2, 8777: 2, 9875: 2, 91452: 2, 3881: 2, 9136: 2, 9847: 2, 25994: 2, 18536: 2, 110391: 2, 71069: 2, 13800: 2, 231830: 2, 228994: 2, 72125: 2, 66589: 2, 14389: 2, 226591: 2, 19070: 2, 9730: 2, 107975: 2, 6747: 2, 56327: 2, 11852: 2, 20394: 2, 83997: 2, 229615: 2, 16564: 2, 15439: 2, 208715: 2, 5537: 2, 9611: 2, 23522: 2, 5192: 2, 23157: 2, 100337564: 2, 140781: 2, 55178: 2, 268697: 2, 1778: 2, 7410: 2, 54919: 2, 92856: 2, 12428: 2, 12323: 2, 12799: 2, 18750: 2, 26395: 2, 20544: 2, 18176: 2, 26046: 2, 53371: 2, 8559: 2, 22200: 2, 10059: 2, 30841: 2, 64216: 2, 6015: 2, 216850: 2, 84108: 2, 233904: 2, 64319: 2, 98386: 2, 57332: 2, 19400: 2, 19043: 2, 8106: 2, 74195: 2, 50997: 2, 23403: 2, 83855: 2, 51150: 2, 25942: 2, 6897: 2, 8087: 2, 57708: 2, 19699: 2, 17859: 2, 1876: 2, 21881: 2, 7023: 2, 6938: 2, 10051: 2, 203068: 2, 233908: 2, 114716: 2, 51548: 2, 83892: 2, 21974: 2, 23580: 2, 79751: 2, 16917: 2, 14248: 2, 50907: 2, 64769: 2, 8531: 2, 4299: 2, 64897: 2, 240283: 2, 74026: 2, 20630: 2, 100986: 2, 85305: 2, 7419: 2, 10016: 2, 66580: 2, 21340: 2, 18044: 2, 71242: 2, 229906: 2, 9014: 2, 208618: 2, 56469: 2, 2109: 2, 9782: 2, 51726: 2, 22325: 2, 22129: 2, 56349: 2, 59009: 2, 29894: 2, 232345: 2, 14862: 2, 10762: 2, 3310: 2, 3836: 2, 225471: 2, 93679: 2, 8019: 2, 201595: 2, 3181: 2, 54499: 2, 57662: 2, 3710: 2, 23530: 2, 66480: 2, 7014: 2, 6238: 2, 107260: 2, 67974: 2, 5504: 2, 67326: 2, 8175: 2, 9212: 2, 10262: 2, 20641: 2, 22826: 2, 11315: 2, 320706: 2, 53323: 2, 72393: 2, 22193: 2, 7750: 2, 71521: 2, 5430: 2, 76787: 2, 23517: 2, 84248: 2, 286887: 2, 5469: 2, 29079: 2, 29927: 2, 6674: 2, 7267: 2, 54822: 2, 218629: 2, 57509: 2, 226: 2, 16195: 2, 64784: 2, 7422: 2, 16978: 2, 12978: 2, 21894: 2, 268903: 2, 80509: 2, 17449: 2, 14266: 2, 216033: 2, 23650: 2, 69597: 2, 18642: 2, 332131: 2, 22027: 2, 211914: 2, 53421: 2, 230073: 2, 17318: 2, 77963: 2, 210293: 2, 19354: 2, 76338: 2, 12649: 2, 75141: 2, 9619: 2, 57619: 2, 5204: 2, 20750: 2, 51280: 2, 20115: 2, 2107: 2, 21991: 2, 84164: 2, 19895: 2, 15260: 2, 380752: 2, 11447: 2, 56495: 2, 68299: 2, 331401: 2, 66713: 2, 380993: 2, 71617: 2, 23354: 2, 225895: 2, 320609: 2, 6801: 2, 56715: 2, 360216: 2, 8915: 2, 76559: 2, 7818: 2, 64393: 2, 728689: 2, 6635: 2, 4288: 2, 144983: 2, 10236: 1, 20648: 1, 71911: 1, 20362: 1, 54004: 1, 57440: 1, 214812: 1, 604: 1, 6141: 1, 53872: 1, 22433: 1, 57261: 1, 13660: 1, 98956: 1, 128866: 1, 84790: 1, 53857: 1, 22230: 1, 68194: 1, 19823: 1, 20264: 1, 66314: 1, 320277: 1, 77038: 1, 109905: 1, 22661: 1, 67109: 1, 21681: 1, 102098: 1, 74255: 1, 550: 1, 20334: 1, 16570: 1, 69940: 1, 26927: 1, 13437: 1, 74498: 1, 1195: 1, 21985: 1, 119504: 1, 1153: 1, 71978: 1, 5036: 1, 3303: 1, 19305: 1, 29127: 1, 75723: 1, 97122: 1, 214895: 1, 73137: 1, 9412: 1, 18521: 1, 76499: 1, 11430: 1, 71743: 1, 108062: 1, 225870: 1, 72729: 1, 56228: 1, 51798: 1, 192167: 1, 66606: 1, 14583: 1, 268721: 1, 66416: 1, 5682: 1, 10061: 1, 222584: 1, 7157: 1, 76448: 1, 9662: 1, 9791: 1, 51003: 1, 216825: 1, 268379: 1, 207214: 1, 73830: 1, 245944: 1, 84376: 1, 71041: 1}
Histogram of the path lengths for control counts
Overlapping genes with the difference of their values
Size: 1109
Average: -62.66275924256087
Median: -4
{13626: 7692, 11537: 5046, 217331: 3866, 16531: 951, 211651: 678, 12421: 641, 22123: 596, 170707: 590, 208263: 546, 21423: 542, 13627: 528, 209446: 521, 22630: 516, 4137: 503, 27374: 498, 13205: 473, 54401: 450, 54726: 438, 67731: 430, 24654: 425, 20466: 402, 7321: 393, 19053: 376, 6622: 360, 66949: 354, 230796: 342, 193034: 299, 11789: 288, 2641: 287, 20586: 268, 12005: 262, 14784: 256, 14265: 253, 11946: 238, 20511: 224, 216799: 211, 17125: 210, 26380: 208, 17283: 191, 11964: 178, 208727: 162, 1080: 162, 14694: 159, 16412: 154, 106025: 151, 27050: 151, 11465: 148, 19401: 142, 26754: 138, 15387: 136, 14828: 135, 18024: 134, 10094: 133, 16825: 133, 99982: 131, 324: 130, 801: 128, 21841: 127, 16924: 123, 19946: 121, 16348: 116, 17975: 116, 15519: 114, 17127: 111, 319178: 109, 15114: 106, 16905: 100, 56438: 98, 328572: 98, 93765: 95, 67838: 95, 15183: 94, 20614: 93, 29875: 90, 50907: 88, 16399: 88, 22223: 85, 244585: 85, 16898: 85, 13711: 84, 21817: 83, 53885: 82, 12314: 79, 545030: 77, 22121: 76, 50525: 76, 66314: 76, 56371: 74, 229906: 74, 11949: 73, 14466: 72, 13629: 71, 56207: 71, 11816: 70, 230908: 70, 19988: 69, 75956: 66, 68193: 64, 17927: 63, 11657: 63, 12265: 62, 22330: 62, 16480: 62, 19182: 61, 67979: 61, 71514: 60, 100503670: 59, 78294: 58, 66725: 57, 19696: 56, 66075: 54, 18148: 53, 67155: 53, 19167: 53, 12540: 53, 74148: 52, 203228: 51, 23988: 50, 21937: 50, 67427: 48, 19184: 48, 19823: 47, 19353: 47, 16202: 45, 69017: 45, 75770: 44, 105689: 44, 7157: 44, 19280: 43, 20115: 42, 53379: 42, 57154: 41, 8904: 41, 18549: 41, 66870: 38, 22690: 38, 74117: 37, 19211: 35, 19122: 35, 110323: 34, 13211: 33, 20910: 33, 26395: 32, 224903: 31, 15450: 31, 67671: 31, 16423: 30, 19934: 29, 66713: 29, 56347: 29, 276770: 29, 15481: 27, 20683: 27, 13665: 26, 84505: 26, 14751: 26, 20742: 26, 20740: 26, 75786: 26, 24252: 25, 11867: 24, 93759: 24, 226049: 23, 22346: 22, 11983: 22, 93760: 22, 21991: 22, 69077: 22, 23881: 22, 271457: 22, 66480: 22, 13043: 22, 14824: 22, 56484: 21, 53356: 21, 192176: 20, 22030: 20, 11459: 20, 76959: 20, 72584: 20, 16438: 20, 27979: 19, 20437: 18, 26398: 18, 20624: 18, 11797: 17, 67039: 17, 232910: 17, 140629: 17, 11518: 17, 66576: 17, 108655: 17, 75646: 16, 21894: 16, 218490: 16, 17755: 16, 51797: 16, 233908: 16, 18810: 16, 14679: 16, 106504: 16, 384309: 15, 76499: 15, 26451: 14, 67118: 14, 103963: 14, 12974: 14, 109113: 14, 224938: 13, 108989: 13, 52440: 12, 13426: 12, 70247: 12, 10808: 12, 108737: 12, 98386: 12, 16400: 12, 16151: 11, 22230: 11, 22153: 11, 11837: 11, 19943: 11, 22629: 11, 12864: 11, 12367: 11, 14281: 10, 110379: 10, 11865: 10, 93687: 10, 211914: 10, 107260: 10, 107045: 10, 14609: 10, 104721: 10, 192662: 10, 59007: 9, 69116: 9, 5430: 9, 21681: 9, 109711: 9, 226180: 9, 15107: 9, 66185: 9, 67891: 9, 26927: 9, 12385: 9, 22213: 8, 11947: 8, 22027: 8, 68942: 8, 234734: 8, 226432: 8, 70675: 8, 21343: 8, 53872: 8, 67972: 8, 100288687: 8, 12417: 8, 67680: 8, 245688: 7, 22186: 7, 386649: 7, 23969: 7, 107932: 7, 56403: 7, 21454: 7, 23094: 7, 18645: 7, 22702: 7, 20641: 7, 69654: 7, 12306: 7, 57320: 6, 26440: 6, 18220: 6, 12013: 6, 22173: 6, 11863: 6, 269774: 6, 56736: 6, 238880: 6, 56258: 6, 4926: 6, 13063: 6, 230075: 6, 55949: 6, 66118: 6, 14800: 6, 26961: 6, 67863: 6, 18519: 6, 26557: 5, 22384: 5, 110446: 5, 83602: 5, 3708: 5, 19989: 5, 21888: 5, 17756: 5, 77134: 5, 11429: 5, 19349: 5, 16765: 5, 18643: 5, 53378: 5, 75717: 4, 83892: 4, 20239: 4, 18130: 4, 28080: 4, 21762: 4, 56515: 4, 15416: 4, 76787: 4, 68572: 4, 232333: 4, 117600: 4, 19164: 4, 14376: 4, 81601: 3, 67186: 3, 21843: 3, 228607: 3, 234663: 3, 51869: 3, 14810: 3, 16826: 3, 71679: 3, 20637: 3, 12334: 3, 57376: 3, 69605: 2, 12234: 2, 227197: 2, 319322: 2, 231225: 2, 208618: 2, 12010: 2, 67204: 2, 18040: 2, 20055: 2, 228829: 2, 100287932: 2, 21872: 2, 64750: 2, 17449: 2, 66589: 2, 211948: 2, 19400: 2, 224111: 2, 17192: 2, 19070: 2, 2665: 2, 19043: 2, 12764: 2, 4544: 2, 67951: 2, 108888: 2, 18750: 2, 20750: 2, 69807: 2, 319565: 2, 12323: 2, 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103583: -10, 23607: -10, 15382: -10, 66510: -10, 19259: -10, 14683: -10, 16687: -10, 12575: -10, 67804: -10, 16402: -10, 12301: -10, 75788: -10, 11835: -11, 232944: -11, 68889: -11, 857: -11, 19249: -11, 224045: -11, 19179: -11, 17060: -11, 4627: -11, 22818: -11, 14580: -11, 22215: -12, 11842: -12, 56505: -12, 642: -12, 74256: -12, 4543: -12, 18626: -12, 22333: -13, 20104: -13, 21969: -13, 17758: -13, 15469: -13, 17254: -13, 66141: -13, 10492: -13, 11958: -14, 59029: -14, 17698: -14, 19650: -14, 658: -14, 18771: -14, 1936: -15, 110355: -15, 12017: -15, 22166: -15, 235072: -15, 66310: -15, 14678: -15, 57181: -16, 22143: -16, 214384: -16, 19060: -16, 20907: -16, 2475: -16, 20850: -16, 22780: -16, 20660: -16, 12388: -16, 13209: -17, 22225: -18, 17995: -18, 30046: -18, 13424: -18, 19384: -18, 17210: -18, 51791: -18, 74126: -18, 12190: -19, 64930: -19, 13681: -19, 12609: -19, 12462: -19, 11920: -20, 17979: -20, 19712: -20, 15405: -20, 19181: -20, 231580: -20, 57423: -20, 9817: -21, 103573: 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Genes unique to the aging counts
Size: 649 Average: 18.476117103235747 Median: 4
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16193: 3, 11950: 3, 52906: 3, 67068: 3, 11765: 3, 3486: 3, 234664: 3, 218138: 3, 78803: 3, 218038: 3, 66471: 3, 13175: 3, 17260: 3, 15170: 3, 17216: 3, 78655: 3, 56088: 3, 54006: 3, 268977: 3, 66201: 3, 23138: 3, 27176: 3, 12805: 3, 20980: 3, 545156: 3, 110911: 3, 217342: 3, 18648: 3, 18479: 3, 20473: 2, 20467: 2, 12268: 2, 1996: 2, 26558: 2, 235442: 2, 20375: 2, 239510: 2, 59272: 2, 10112: 2, 114548: 2, 100040551: 2, 79709: 2, 100044627: 2, 55109: 2, 51008: 2, 83767: 2, 26417: 2, 22317: 2, 26414: 2, 5926: 2, 18212: 2, 112407: 2, 22288: 2, 12023: 2, 59125: 2, 18163: 2, 20195: 2, 20194: 2, 22222: 2, 59069: 2, 18107: 2, 380601: 2, 18103: 2, 11957: 2, 110253: 2, 52892: 2, 20103: 2, 228998: 2, 22138: 2, 239217: 2, 231003: 2, 11857: 2, 104001: 2, 20021: 2, 24113: 2, 3633: 2, 224805: 2, 15903: 2, 11807: 2, 11804: 2, 67089: 2, 232975: 2, 69131: 2, 13824: 2, 13819: 2, 214498: 2, 21982: 2, 226778: 2, 85464: 2, 67025: 2, 21951: 2, 19896: 2, 269700: 2, 66923: 2, 11625: 2, 232807: 2, 28000: 2, 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100494: 2, 18573: 2, 2186: 2, 53376: 2, 18545: 2, 231532: 2, 12386: 2, 69727: 2, 69726: 2, 67673: 2, 67664: 2, 211006: 2, 4144: 2, 20524: 2, 20512: 2, 12315: 2, 18451: 2, 94190: 1, 83945: 1, 4007: 1, 8073: 1, 5962: 1, 433926: 1, 282323: 1, 11980: 1, 9897: 1, 16019: 1, 106039: 1, 13822: 1, 24055: 1, 26092: 1, 69091: 1, 21929: 1, 52637: 1, 23950: 1, 73086: 1, 13690: 1, 13685: 1, 28006: 1, 7458: 1, 19744: 1, 269587: 1, 56541: 1, 19652: 1, 100502698: 1, 56440: 1, 15452: 1, 99412: 1, 78920: 1, 17380: 1, 9185: 1, 19417: 1, 76742: 1, 97165: 1, 80708: 1, 234267: 1, 4868: 1, 66237: 1, 70312: 1, 10907: 1, 66194: 1, 72330: 1, 68202: 1, 66144: 1, 229949: 1, 66108: 1, 63958: 1, 14791: 1, 227753: 1, 233871: 1, 18813: 1, 108911: 1, 108679: 1, 14457: 1, 16498: 1, 114774: 1, 235604: 1, 57410: 1, 12322: 1, 319504: 1}
After thinking about it, I added one final metric to sift through the list of potential aging genes: pubmed search results. Basically I search for the gene name along with the keyword “aging” and count how many search results are returned. This number is divided by the maximum value found from across the whole dataset to return a percentile. The same is done for the overlaps, the overlap count for a particular gene is divided by the maximum value found across the whole dataset. The two percentiles are added together, each with a max value of 1, together with a max value of 2, and the results are sorted based on the combined hybrid value. The results are shown below along with a boolean that shows whether the gene is found in the GenAge dataset of identified genes related to aging. As you can see many of the top results are found in the GenAge dataset, which highlights how this enriching process works and how the yet unverified genes provides a shortlist for further research to further complete the GenAge dataset.
UBC: (1.0712209302325582, False)
EED: (1.052, False)
PTEN: (1.0302204457364341, True)
APC: (1.0222262596899225, False)
LMNA: (1.0156855620155039, True)
NLRP3: (1.0130208333333333, False)
MAPT: (1.0109617248062015, True)
NFE2L2: (1.0087209302325582, True)
SET: (1.005874515503876, False)
JUN: (1.0052083333333333, True)
SIRT1: (1.0051477713178294, True)
APOE: (1.0046027131782946, True)
FOS: (1.003391472868217, True)
STAT3: (1.0032097868217054, True)
RAN: (1.00296753875969, False)
APP: (1.0028464147286822, True)
GFAP: (1.0012718023255813, False)
CS: (1.0010295542635659, False)
PSEN1: (1.0008478682170543, True)
EGFR: (1.0007267441860466, True)
TNF: (1.000484496124031, True)
MET: (1.0003633720930232, False)
SRC: (1.0003028100775193, False)
COPE: (1.0003028100775193, False)
MYC: (1.0002422480620154, True)
AR: (1.0002422480620154, True)
IL6: (1.0001816860465116, True)
ATM: (1.0001211240310077, True)
SOD1: (1.0001211240310077, True)
BAX: (1.0001211240310077, True)
REST: (1.0001211240310077, False)
ENG: (1.0000605620155039, False)
LRRK2: (0.9796942829457365, False)
CDKN1A: (0.9741211240310077, True)
FANCD2: (0.9729941860465116, False)
HGS: (0.9663028100775194, False)
FOXO3: (0.9535140503875968, True)
CDKN2A: (0.9250886627906977, True)
PCNA: (0.8863633720930233, True)
RUNX2: (0.8802407945736435, False)
SNCA: (0.849453488372093, False)
KEAP1: (0.8492112403100774, False)
ABR: (0.8101211240310078, False)
GRN: (0.8035746124031008, True)
H2AX: (0.8028478682170543, False)
SOX2: (0.7861802325581395, False)
PARP1: (0.7721816860465116, True)
CASP3: (0.7627873062015504, False)
FOXP3: (0.755953488372093, False)
NSF: (0.7203633720930233, False)
BRCA1: (0.7143633720930233, True)
BCR: (0.6942422480620154, False)
HTT: (0.6938265503875969, True)
AKT1: (0.6710901162790698, True)
TARDBP: (0.6696928294573644, False)
STING1: (0.6686119186046512, False)
NCL: (0.6515082364341085, False)
MSN: (0.649936531007752, False)
TYR: (0.6310901162790697, False)
CFD: (0.6277577519379844, False)
AGA: (0.6266056201550387, False)
ALB: (0.606359011627907, False)
PTGS2: (0.6007873062015504, True)
SMAD2: (0.5993323643410853, False)
SQSTM1: (0.5984685077519379, True)
APOB: (0.5642422480620154, False)
MBP: (0.5623028100775195, False)
BMAL1: (0.5607267441860465, False)
SIRT2: (0.5602422480620155, False)
FUS: (0.5390901162790698, False)
RHOA: (0.5367267441860465, False)
RELA: (0.5281211240310077, True)
SMAD3: (0.5194447674418605, False)
MDM2: (0.5083028100775194, True)
ATG5: (0.48914777131782944, False)
STAT1: (0.48115067829457364, False)
MAP2: (0.4612718023255814, False)
GAPDH: (0.45933236434108526, False)
SP1: (0.4524830426356589, True)
ATF4: (0.4462422480620155, False)
BID: (0.4362422480620155, False)
CIT: (0.43284786821705423, False)
ESR1: (0.4323633720930232, True)
FMR1: (0.43038468992248063, False)
GSK3B: (0.4266041666666667, True)
ATG7: (0.4161211240310077, False)
BRAF: (0.4133323643410852, False)
CLU: (0.4122422480620155, True)
NANOG: (0.39834011627906973, False)
CDK5: (0.39812112403100774, False)
CTNNB1: (0.38453488372093025, True)
AIP: (0.37768846899224806, False)
BRCA2: (0.3730295542635659, True)
MYD88: (0.3721211240310077, False)
YAP1: (0.366484496124031, False)
RAC1: (0.3525421511627907, False)
SPP1: (0.3442422480620155, False)
EZH2: (0.33618168604651166, False)
CDC42: (0.32466182170542635, True)
TRP53: (0.3225436046511628, False)
ADAM10: (0.3047252906976744, False)
UNK: (0.30227664728682174, False)
VCP: (0.291609011627907, True)
HDAC1: (0.290718023255814, True)
CDK1: (0.29054505813953485, True)
RB1: (0.286484496124031, True)
TRPV1: (0.2753163759689923, True)
SLC6A4: (0.2749646317829458, False)
CREB1: (0.2743028100775194, True)
APOA1: (0.2687785852713178, False)
PARK7: (0.26533236434108526, False)
MITF: (0.25909011627906975, False)
KDR: (0.25812112403100773, False)
SNAP25: (0.25314486434108524, False)
MVP: (0.25060562015503873, False)
GLS: (0.25036337209302323, False)
INA: (0.24921124031007752, False)
POU5F1: (0.24727567829457364, False)
PML: (0.24636337209302325, True)
E2F1: (0.2462422480620155, True)
DSP: (0.24612112403100775, False)
COL3A1: (0.24090843023255812, False)
PRNP: (0.2396308139534884, False)
PREB: (0.23545058139534886, False)
HSPA5: (0.2338701550387597, False)
TOMM40: (0.22757315891472868, False)
DLG4: (0.22441957364341086, False)
CD47: (0.22193798449612404, False)
GATA4: (0.21812112403100775, False)
BIN1: (0.2167078488372093, False)
CNP: (0.21212112403100775, False)
SORL1: (0.21212112403100775, False)
SMAD1: (0.20925872093023257, False)
TBK1: (0.20830281007751936, False)
TPR: (0.20733236434108526, False)
LAMP2: (0.2065421511627907, False)
SIRT4: (0.2062422480620155, False)
DRD2: (0.20618023255813953, False)
REL: (0.20587596899224808, False)
MAPK1: (0.20417877906976745, False)
PRKN: (0.20212112403100777, False)
MYOD1: (0.20120833333333335, False)
SFN: (0.20084786821705428, False)
SSB: (0.20060562015503877, False)
FBXO32: (0.20051308139534885, False)
PER1: (0.1982422480620155, False)
ITCH: (0.19671947674418605, False)
FER: (0.19606056201550387, False)
UCHL1: (0.19235901162790697, True)
VIM: (0.19212112403100776, False)
ATG16L1: (0.19074176356589145, False)
CST3: (0.18812112403100775, False)
BCL2L1: (0.18636337209302326, False)
MCL1: (0.1842422480620155, False)
MEF2C: (0.1841816860465116, False)
FADD: (0.18236337209302325, False)
GAA: (0.18077277131782946, False)
MECP2: (0.18012112403100775, False)
HDAC4: (0.17959593023255815, False)
SMAD4: (0.17684786821705425, False)
CD63: (0.17678730620155036, False)
GBA1: (0.17448158914728684, False)
VDAC1: (0.1721816860465116, False)
JAK1: (0.17212112403100774, False)
EIF4E: (0.17109011627906978, False)
CBL: (0.17109011627906978, False)
ARNT: (0.17084786821705428, False)
HDAC3: (0.170843507751938, True)
APEX1: (0.16824224806201551, True)
CDKN1B: (0.16806056201550387, False)
TRAF6: (0.167625, False)
FYN: (0.16460562015503877, False)
NIN: (0.16454505813953488, False)
ADAR: (0.16284786821705427, False)
HDAC2: (0.16254505813953488, True)
TSC1: (0.16150678294573642, False)
PIN1: (0.16139147286821706, True)
OPTN: (0.16060562015503876, False)
EP300: (0.15955426356589147, True)
HDAC6: (0.15806056201550386, False)
ACTB: (0.14942296511627906, False)
TBP: (0.1485998062015504, True)
SMAD7: (0.1482422480620155, False)
KCTD13: (0.14777277131782945, False)
YY1: (0.146968992248062, False)
ELAVL1: (0.14539292635658913, False)
GSTP1: (0.1422422480620155, True)
HNRNPD: (0.1375106589147287, False)
VHL: (0.13557461240310079, False)
RAG1: (0.1342422480620155, False)
FASN: (0.13406056201550387, False)
NF1: (0.13272674418604652, False)
PFAS: (0.13260562015503877, False)
ATG12: (0.131328003875969, False)
GSTM1: (0.13018168604651162, False)
NTRK2: (0.13012112403100776, False)
LDHA: (0.12812112403100775, False)
NNT: (0.1267267441860465, False)
HES1: (0.12660562015503876, False)
BAG3: (0.12660416666666666, False)
BACH1: (0.126484496124031, False)
RPS6: (0.12418168604651163, False)
CTSB: (0.12296463178294574, False)
PTN: (0.12212112403100775, False)
ITGB1: (0.12071366279069767, False)
B2M: (0.12036337209302325, False)
KCNMA1: (0.11981928294573643, False)
CD81: (0.11975193798449613, False)
ATXN2: (0.11933236434108527, False)
AGO2: (0.11884786821705426, False)
VPS35: (0.11666618217054264, False)
MAP1LC3A: (0.11618168604651163, False)
CEBPA: (0.11587306201550387, True)
HSPA8: (0.11550242248062016, True)
ATXN1: (0.11503924418604651, False)
GJA1: (0.11448304263565892, False)
PTPRC: (0.11430281007751938, False)
MME: (0.11406056201550388, False)
RACK1: (0.11332364341085271, False)
C4B: (0.11212112403100775, False)
DYRK1A: (0.11212112403100775, False)
NEDD4: (0.11161046511627906, False)
STUB1: (0.11144767441860465, True)
GRB2: (0.11101356589147286, True)
LGALS3: (0.11012112403100775, False)
TFE3: (0.11008333333333334, False)
CTSD: (0.1082422480620155, False)
PRKDC: (0.10812112403100775, True)
ZEB1: (0.10812112403100775, False)
GLB1: (0.10799854651162791, False)
BUB1B: (0.1062422480620155, True)
AMPH: (0.10618168604651163, False)
CREBBP: (0.10617587209302326, True)
MAPK3: (0.10612112403100775, True)
TNFRSF1A: (0.10472383720930233, False)
TTN: (0.10412112403100775, False)
KDM1A: (0.10361046511627908, False)
ILK: (0.10296753875968993, False)
TJP1: (0.10048449612403101, False)
TWIST1: (0.10012112403100776, False)
MEN1: (0.09999127906976743, False)
CRYAB: (0.09878730620155039, False)
RARA: (0.09859253875968993, False)
PDGFRA: (0.09824224806201551, True)
SMARCA4: (0.09797529069767441, False)
NPC1: (0.09769573643410853, False)
TRIM59: (0.09634738372093023, False)
TCF7L2: (0.09606056201550388, False)
EEF2: (0.0947829457364341, True)
LMNB1: (0.09248449612403101, True)
ITGAM: (0.09212112403100775, False)
SPI1: (0.09212112403100775, False)
RHEB: (0.09206056201550387, False)
PKM: (0.09193217054263567, False)
LONP1: (0.08890843023255814, False)
TCF4: (0.08812112403100775, False)
EIF4EBP1: (0.08806056201550387, False)
RAB7: (0.08666618217054263, False)
PTPN11: (0.0862422480620155, True)
GRK2: (0.08618168604651162, False)
ERCC8: (0.08612112403100775, True)
NPM1: (0.08490552325581395, False)
CMBL: (0.08484786821705427, False)
MELK: (0.08466618217054264, False)
DLD: (0.08424224806201551, False)
CALR: (0.08266618217054264, False)
NCAM1: (0.08236337209302326, False)
MCM2: (0.08218168604651163, False)
RIGI: (0.08212112403100776, False)
ANXA1: (0.08212112403100776, False)
TRAF2: (0.08199854651162791, False)
IGF2R: (0.08029554263565893, False)
PHB2: (0.08012112403100775, False)
PAX3: (0.08012112403100775, False)
EIF5A: (0.07999854651162791, False)
PRMT1: (0.0792718023255814, False)
SHANK3: (0.07853197674418605, False)
PTK2: (0.07830281007751938, True)
PAK1: (0.07818168604651163, False)
SNAI1: (0.07812112403100775, False)
ISG15: (0.0772718023255814, False)
PRDX1: (0.07721124031007752, True)
USP7: (0.07701356589147287, False)
HK1: (0.0762422480620155, False)
TNFAIP3: (0.07606056201550387, False)
AIFM1: (0.0759985465116279, True)
COL4A2: (0.0752718023255814, False)
PSAP: (0.07471947674418605, False)
NACA: (0.07466618217054263, False)
MGA: (0.07430135658914729, False)
NR3C1: (0.07418023255813953, True)
WWTR1: (0.07412112403100775, False)
GSN: (0.07406056201550387, False)
MAP1B: (0.07393798449612403, False)
HSP90AA1: (0.07314631782945737, True)
ARID1A: (0.07302810077519381, False)
PRDX2: (0.0722422480620155, False)
DDB1: (0.07217587209302326, False)
ASCL1: (0.07212112403100775, False)
RECQL: (0.07212112403100775, False)
GAK: (0.07212112403100775, False)
SLC1A2: (0.07205038759689923, False)
ATF2: (0.07048449612403102, True)
PRKCA: (0.07024224806201551, True)
NF2: (0.07024224806201551, False)
SLC1A3: (0.07012112403100776, False)
APOA2: (0.07012112403100776, False)
OTX2: (0.06987596899224807, False)
TCF3: (0.06942877906976744, True)
NFE2: (0.06933236434108528, False)
MAVS: (0.06921124031007753, False)
PRMT5: (0.06912887596899225, False)
ACLY: (0.06890843023255815, False)
SF1: (0.06860562015503877, False)
GABARAP: (0.06824224806201551, False)
RPTOR: (0.06812112403100776, False)
G3BP1: (0.06713032945736434, False)
HNRNPA1: (0.0670295542635659, False)
CHMP2B: (0.06666618217054264, False)
USP48: (0.06655910852713179, False)
YWHAZ: (0.06653924418604651, True)
AHSG: (0.06612112403100776, False)
PIK3R1: (0.06533236434108528, True)
GRIN2B: (0.0650295542635659, False)
EEF1A1: (0.06481879844961241, True)
PLP1: (0.06442393410852713, False)
SDHB: (0.06363517441860465, False)
NONO: (0.06357461240310078, False)
LBR: (0.06284786821705426, False)
UBQLN2: (0.06254505813953488, False)
FBXW7: (0.062242248062015504, False)
HDAC5: (0.06096608527131783, False)
RB1CC1: (0.06094137596899225, False)
PGK1: (0.06084786821705426, False)
TIA1: (0.060781492248062015, False)
LIPC: (0.06024079457364341, False)
RTN4: (0.06011967054263566, False)
WDTC1: (0.0599578488372093, False)
YBX1: (0.05993798449612403, False)
ELL: (0.05957461240310078, False)
FOXP1: (0.059514050387596905, False)
TOP2A: (0.05945348837209303, True)
STAT5A: (0.05933236434108528, True)
TSG101: (0.05915067829457365, False)
FLNA: (0.058604166666666666, False)
AXIN1: (0.05859399224806202, False)
SETDB1: (0.058301356589147285, False)
HSPA1A: (0.05824224806201551, True)
PTPN6: (0.05818168604651163, False)
ACOX1: (0.05806056201550388, False)
PRDX3: (0.056726744186046514, False)
UBB: (0.05636337209302326, True)
RPA1: (0.05636337209302326, True)
ZEB2: (0.056242248062015505, False)
MDM4: (0.05612112403100775, False)
APLP2: (0.05612112403100775, False)
CDC20: (0.05612112403100775, False)
SDHA: (0.05606056201550388, False)
CAMK2A: (0.05606056201550388, False)
STMN1: (0.054545058139534884, False)
HBB: (0.054242248062015504, False)
BCL2L11: (0.05412112403100775, False)
TRIM28: (0.05412112403100775, False)
BAG1: (0.05412112403100775, False)
MAP2K1: (0.05405910852713178, False)
MAP3K5: (0.05381686046511628, True)
ITPR1: (0.053574612403100776, False)
MYH9: (0.05345058139534884, False)
HNRNPK: (0.05344476744186047, False)
HCN1: (0.05321124031007752, False)
PFN1: (0.05309011627906977, False)
FOXL2: (0.05260562015503876, False)
ID3: (0.05212112403100775, False)
SATB1: (0.05212112403100775, False)
PURA: (0.052060562015503874, False)
PDIA3: (0.05114922480620155, False)
DDX3X: (0.05088808139534884, False)
HNRNPA2B1: (0.050723837209302326, False)
SIN3A: (0.05052616279069767, True)
VAMP2: (0.05030281007751938, False)
STRAP: (0.05024224806201551, False)
HMGB2: (0.05006056201550388, True)
SKP1: (0.049150678294573646, False)
DCTN1: (0.049022286821705424, False)
NDUFS4: (0.048242248062015505, False)
SFPQ: (0.04817877906976744, False)
ITGB2: (0.04812112403100775, False)
TGM2: (0.04751114341085272, False)
ESRRB: (0.046888081395348835, False)
YWHAE: (0.04676550387596899, False)
HAP1: (0.0465406976744186, False)
TOP1: (0.04648449612403101, True)
IRAK1: (0.04618168604651163, False)
ENO1: (0.04612112403100775, False)
HSPA9: (0.045390019379844965, True)
SMARCA2: (0.04453633720930233, False)
ACAT1: (0.044484496124031006, False)
PSMD3: (0.044337209302325584, False)
SIRPA: (0.044181686046511626, False)
IKBKB: (0.04412112403100775, True)
NEFL: (0.04309011627906977, False)
ITM2B: (0.0430281007751938, False)
UBE3A: (0.042726744186046516, False)
SLC12A2: (0.04254505813953489, False)
RIF1: (0.04236337209302326, False)
NCOR1: (0.04224224806201551, True)
DHCR7: (0.04224224806201551, False)
CISD1: (0.04206056201550388, False)
KAT5: (0.04181686046511628, False)
GNS: (0.041635174418604655, False)
ITGB3: (0.041332364341085275, False)
DDX5: (0.04108866279069767, False)
SPOP: (0.04100920542635659, False)
GNAS: (0.040726744186046514, False)
ZBTB7B: (0.04070494186046512, False)
PLCG2: (0.04060562015503876, True)
MAPK8: (0.04060562015503876, True)
NDRG1: (0.040545058139534886, False)
CYCS: (0.04048449612403101, False)
TPM1: (0.04036337209302326, False)
HOXA9: (0.040242248062015505, False)
CPT2: (0.04012112403100775, False)
SLC3A2: (0.04012112403100775, False)
TAP1: (0.04005910852713178, False)
HSPD1: (0.0399985465116279, True)
VCL: (0.03999709302325581, False)
CEBPD: (0.0395140503875969, False)
UBE2C: (0.039385658914728686, False)
CHUK: (0.038847868217054264, False)
CDH2: (0.03848449612403101, False)
BCLAF1: (0.0384656007751938, False)
NSUN2: (0.03830281007751938, False)
EGLN1: (0.0382422480620155, False)
YWHAQ: (0.038218992248062016, False)
SMAD5: (0.03812112403100775, False)
TOR1AIP1: (0.03809496124031008, False)
HSPB2: (0.038060562015503875, False)
ARF1: (0.03709011627906977, False)
BIRC3: (0.03696753875968992, False)
RNF8: (0.03690843023255814, False)
BAG2: (0.03654505813953488, False)
CUL3: (0.03654360465116279, False)
SUFU: (0.036484496124031006, False)
YWHAB: (0.03639922480620155, False)
CFLAR: (0.0362422480620155, False)
GMPS: (0.03612112403100775, False)
KAT8: (0.03612112403100775, False)
ASTN1: (0.03609496124031008, False)
PPP1R9B: (0.0360343992248062, False)
MAP2K4: (0.03593798449612404, False)
CYLD: (0.03593653100775194, False)
TPT1: (0.03574903100775194, False)
OGDH: (0.035332364341085276, False)
HSPA1B: (0.03460562015503876, True)
FERMT2: (0.03448449612403101, False)
SHARPIN: (0.03447722868217054, False)
TCP1: (0.03442248062015504, False)
EHMT2: (0.03436337209302326, False)
MAP1A: (0.03436337209302326, False)
IFITM3: (0.03424224806201551, False)
LRP2: (0.034121124031007755, True)
NRXN1: (0.034121124031007755, False)
CCAR2: (0.034121124031007755, False)
NUPR1: (0.034121124031007755, False)
IGF2BP1: (0.034121124031007755, False)
CTBP2: (0.034121124031007755, False)
RHOB: (0.034121124031007755, False)
ATP1A1: (0.03406056201550388, False)
SNX27: (0.03406056201550388, False)
ITGA2B: (0.03248013565891473, False)
NBR1: (0.03236337209302326, False)
ALDH1L1: (0.032242248062015505, False)
SMURF1: (0.032242248062015505, False)
RPS3: (0.032234980620155035, False)
GAB2: (0.03212112403100775, False)
S100A10: (0.03212112403100775, False)
DLAT: (0.03212112403100775, False)
BRSK2: (0.031981104651162794, False)
POU2F1: (0.03169573643410853, False)
CBX3: (0.03133236434108527, False)
ACO2: (0.031090116279069765, False)
DNM1: (0.031088662790697674, False)
PRDX5: (0.03090843023255814, False)
ALDOA: (0.03090552325581395, False)
MSX1: (0.030726744186046512, False)
ELAVL4: (0.030363372093023255, False)
ILF3: (0.03030281007751938, False)
GLUD1: (0.03030281007751938, False)
PRKCE: (0.030242248062015503, False)
CUX1: (0.03012112403100775, False)
TAL1: (0.03012112403100775, False)
THRB: (0.03012112403100775, False)
PSMB5: (0.030060562015503875, False)
ATP5F1A: (0.029926356589147288, False)
SYNGAP1: (0.02975484496124031, False)
TPI1: (0.029453488372093023, False)
XPO1: (0.02933236434108527, False)
HUWE1: (0.0293265503875969, False)
GRIN1: (0.029271802325581395, False)
HSP90AB1: (0.029149224806201548, False)
PPP2CB: (0.029133236434108527, False)
TRAF3: (0.029090116279069766, False)
RANBP2: (0.029090116279069766, False)
TUBA4A: (0.02902955426356589, False)
GRIA2: (0.028847868217054266, False)
ITGB4: (0.028847868217054266, False)
UBA1: (0.02878730620155039, False)
TAPBP: (0.028709302325581394, False)
CERS2: (0.02866327519379845, False)
APH1A: (0.028423934108527133, False)
TRIM21: (0.028363372093023257, False)
RBBP4: (0.028363372093023257, False)
SMC3: (0.028363372093023257, False)
PPIA: (0.028361918604651162, False)
MDH1: (0.028242248062015505, False)
RDX: (0.028242248062015505, False)
CIITA: (0.02823934108527132, False)
CARM1: (0.02818168604651163, False)
ITGA5: (0.028121124031007753, False)
TNKS: (0.028121124031007753, False)
ATP1A2: (0.028121124031007753, False)
SYVN1: (0.028121124031007753, False)
KLF10: (0.028121124031007753, False)
RBM3: (0.028060562015503877, False)
RASGRF1: (0.028060562015503877, False)
CHD4: (0.02751114341085271, False)
MATR3: (0.02745348837209302, False)
MTTP: (0.026847868217054264, False)
KCNQ2: (0.02672674418604651, False)
UHRF1: (0.02672674418604651, False)
DPYSL2: (0.026533430232558143, False)
OLA1: (0.026484496124031007, False)
KIF1A: (0.02642393410852713, False)
HADHA: (0.026363372093023255, False)
PLCG1: (0.026242248062015503, False)
EIF4G1: (0.026242248062015503, False)
RBX1: (0.02617732558139535, False)
ATP1A3: (0.02612112403100775, False)
INVS: (0.025994186046511627, False)
CDKL5: (0.025809593023255813, False)
SUZ12: (0.025574612403100775, False)
BIRC2: (0.0255140503875969, False)
DAB2: (0.025506782945736432, False)
DYNLL1: (0.025382751937984498, False)
CUL1: (0.025271802325581395, False)
NEDD4L: (0.025271802325581395, False)
ITGA6: (0.025271802325581395, False)
ACTG1: (0.025265988372093026, False)
ATP6V1A: (0.025203972868217055, False)
BUB3: (0.025090116279069766, True)
DHX9: (0.025028100775193796, False)
TFAP2A: (0.024968992248062018, True)
JMY: (0.02496608527131783, False)
SPTBN1: (0.024846414728682167, False)
CUL4A: (0.02478294573643411, False)
PRDX4: (0.024726744186046513, False)
USP25: (0.024726744186046513, False)
CYC1: (0.024726744186046513, False)
AMFR: (0.024666182170542637, False)
ACTN4: (0.02460562015503876, False)
AGO1: (0.02448449612403101, False)
TAF15: (0.024363372093023257, False)
ATAD3A: (0.024242248062015505, False)
CDC37: (0.024242248062015505, False)
CLUH: (0.024237887596899224, False)
STXBP1: (0.024180232558139534, False)
SLC25A4: (0.024174418604651166, False)
CDK12: (0.024121124031007753, False)
EPAS1: (0.024121124031007753, False)
CIRBP: (0.024121124031007753, False)
UBQLN1: (0.024121124031007753, False)
P4HB: (0.024121124031007753, False)
CNOT8: (0.02343895348837209, False)
RGS14: (0.023329457364341083, False)
CACYBP: (0.023029554263565892, False)
ACTA1: (0.02290697674418605, False)
BTG1: (0.022844961240310074, False)
SYNE2: (0.02272674418604651, False)
UBE2N: (0.022660368217054264, False)
COX4I1: (0.022542151162790697, False)
MDH2: (0.022484496124031007, False)
CBLB: (0.022484496124031007, False)
CKAP4: (0.02242393410852713, False)
PFKP: (0.02242393410852713, False)
GAB1: (0.02230281007751938, False)
STIP1: (0.022242248062015503, False)
ASPH: (0.022242248062015503, False)
NDN: (0.022237887596899226, False)
ZFR: (0.02212112403100775, False)
TKT: (0.02212112403100775, False)
DIAPH1: (0.02212112403100775, False)
CAMK2D: (0.02212112403100775, False)
PBRM1: (0.02212112403100775, False)
MYOCD: (0.02212112403100775, False)
CITED2: (0.02212112403100775, False)
SOX17: (0.02212112403100775, False)
UBR5: (0.02212112403100775, False)
IGHM: (0.022060562015503875, False)
COPS5: (0.021992732558139536, False)
EXOSC4: (0.02180232558139535, False)
SLC29A1: (0.02139001937984496, False)
RPLP0: (0.02133236434108527, False)
PLEC: (0.02133236434108527, False)
FITM2: (0.021079941860465117, False)
ARRB2: (0.02090843023255814, False)
SUN2: (0.02090843023255814, False)
MCM3: (0.020847868217054265, False)
UVRAG: (0.02084641472868217, False)
MAP2K7: (0.020726744186046513, False)
MTA1: (0.02060562015503876, False)
PABPC1: (0.020540697674418604, False)
EZR: (0.02048449612403101, False)
PPP2CA: (0.020481589147286823, False)
RCC1: (0.020423934108527133, False)
USP5: (0.020363372093023257, False)
TRPS1: (0.02030281007751938, False)
PCBP1: (0.02030281007751938, False)
NDUFV2: (0.02030281007751938, False)
SPAST: (0.020242248062015505, False)
NDUFS1: (0.020242248062015505, False)
LAMC1: (0.020242248062015505, False)
GIGYF2: (0.020242248062015505, False)
ARL8B: (0.020232073643410852, False)
MEF2D: (0.02018168604651163, False)
PGAM1: (0.02018168604651163, False)
NCOA1: (0.020121124031007753, False)
CFL1: (0.020121124031007753, False)
PDE1A: (0.020121124031007753, False)
TRIM29: (0.020121124031007753, False)
MAPK10: (0.020121124031007753, False)
PRPF19: (0.020121124031007753, False)
APH1B: (0.020121124031007753, False)
LRP8: (0.020121124031007753, False)
COPA: (0.020118217054263567, False)
HPRT1: (0.020060562015503876, False)
DLST: (0.020060562015503876, False)
NPHP4: (0.020050387596899227, False)
HSPA4: (0.019998546511627906, False)
ELF5: (0.019935077519379847, False)
JUP: (0.019813953488372095, False)
PRKACA: (0.019574612403100773, False)
RPL13A: (0.01926889534883721, False)
CUL2: (0.019211240310077517, False)
DLGAP1: (0.019146317829457363, False)
CSTB: (0.019090116279069765, False)
IKBKG: (0.019026647286821706, False)
WDR77: (0.018968992248062012, False)
TRIM32: (0.018968992248062012, False)
RAD23B: (0.01890843023255814, False)
HADH: (0.01890843023255814, False)
TNIK: (0.018844961240310078, False)
POLR2A: (0.018657461240310078, False)
HSP90B1: (0.01860562015503876, False)
SF3B4: (0.01860562015503876, False)
MTAP: (0.01842393410852713, False)
SALL4: (0.01842393410852713, False)
CMAS: (0.018363372093023255, False)
UPF1: (0.01830281007751938, False)
HHEX: (0.018242248062015503, False)
TOLLIP: (0.018242248062015503, False)
EIF4A3: (0.018242248062015503, False)
DYNC1H1: (0.018242248062015503, False)
GMDS: (0.018181686046511627, False)
RAB1A: (0.018181686046511627, False)
DOCK11: (0.01812112403100775, False)
MAFG: (0.01812112403100775, False)
CBX5: (0.01812112403100775, False)
GLUL: (0.01812112403100775, False)
BCL11B: (0.01812112403100775, False)
KPNA2: (0.01812112403100775, False)
SIX3: (0.01812112403100775, False)
VAX2: (0.01812112403100775, False)
UBE4B: (0.018060562015503875, False)
NCSTN: (0.018060562015503875, False)
NDUFA9: (0.018060562015503875, False)
NRCAM: (0.018060562015503875, False)
IQGAP1: (0.017813953488372093, False)
HNRNPU: (0.017754844961240312, False)
PSMA3: (0.017573158914728684, False)
TRA2B: (0.017150678294573642, False)
TLN1: (0.017090116279069766, False)
PDIA6: (0.017088662790697675, False)
PPP2R1A: (0.017084302325581398, False)
MYH10: (0.017029554263565894, False)
EWSR1: (0.016967538759689923, False)
CDC5L: (0.016906976744186047, False)
CLTC: (0.016905523255813952, False)
EIF5: (0.016847868217054265, False)
USP8: (0.016847868217054265, False)
NGLY1: (0.01678730620155039, False)
SCFD1: (0.016666182170542637, False)
UBR4: (0.016666182170542637, False)
HSPA2: (0.01660562015503876, False)
ALYREF: (0.01660562015503876, False)
SCN2A: (0.016545058139534885, False)
ANXA5: (0.01648449612403101, False)
CBX1: (0.01648449612403101, False)
TCERG1: (0.016423934108527133, False)
RPS23: (0.016423934108527133, False)
TRO: (0.016423934108527133, False)
ERCC4: (0.016363372093023257, True)
TCF12: (0.016363372093023257, False)
ATP12A: (0.016351744186046513, False)
CAPN2: (0.01630281007751938, False)
TIAL1: (0.01630281007751938, False)
RPS27A: (0.016236434108527133, False)
KALRN: (0.01618168604651163, False)
CNTN1: (0.01618168604651163, False)
KIF2A: (0.016121124031007752, False)
VPS26A: (0.016121124031007752, False)
PDLIM5: (0.016121124031007752, False)
DVL1: (0.016121124031007752, False)
P4HA1: (0.016121124031007752, False)
UTRN: (0.016121124031007752, False)
PLS3: (0.016121124031007752, False)
SMAD9: (0.016121124031007752, False)
SYN2: (0.016060562015503876, False)
PPP1CA: (0.01605184108527132, True)
ATIC: (0.015756298449612405, False)
DMRT2: (0.015756298449612405, False)
G3BP2: (0.015574612403100775, False)
ELAVL2: (0.0155140503875969, False)
CHCHD3: (0.015450581395348838, False)
RPS2: (0.01526889534883721, False)
COX5A: (0.015150678294573644, False)
SMARCB1: (0.015090116279069768, False)
TNPO1: (0.014968992248062016, False)
ITGA3: (0.014847868217054264, False)
ALDOC: (0.014666182170542635, False)
ATP5F1B: (0.014664728682170542, False)
IKZF3: (0.01460562015503876, False)
ATP2B1: (0.01460562015503876, False)
PCSK1: (0.014545058139534883, False)
SPAG6L: (0.014534883720930232, False)
MBD2: (0.014484496124031007, False)
HIP1R: (0.014484496124031007, False)
PSMA7: (0.014484496124031007, False)
BTD: (0.014423934108527133, False)
CTTN: (0.01442248062015504, False)
AGAP2: (0.014419573643410854, False)
MTHFD1: (0.014363372093023257, False)
NDUFV1: (0.014363372093023257, False)
PIK3C2A: (0.014363372093023257, False)
CENPE: (0.01430281007751938, False)
PDIA4: (0.01430281007751938, False)
CHMP4B: (0.01430281007751938, False)
RBBP7: (0.014301356589147288, False)
AATF: (0.014242248062015505, False)
PPM1B: (0.014242248062015505, False)
DNAJB1: (0.014242248062015505, False)
VAMP3: (0.014242248062015505, False)
MARK4: (0.014242248062015505, False)
EYA1: (0.014242248062015505, False)
LTBP1: (0.014181686046511629, False)
DEAF1: (0.014181686046511629, False)
DCLK1: (0.014181686046511629, False)
EPS8: (0.014121124031007752, True)
KRT6A: (0.014121124031007752, False)
PCP2: (0.014121124031007752, False)
PIAS1: (0.014121124031007752, False)
NEFH: (0.014121124031007752, False)
PRPF8: (0.014121124031007752, False)
EGLN3: (0.014121124031007752, False)
HIF3A: (0.014121124031007752, False)
MAP3K7: (0.014121124031007752, False)
SMYD3: (0.014121124031007752, False)
EPS15: (0.014121124031007752, False)
DNM3: (0.014121124031007752, False)
ETFA: (0.014121124031007752, False)
EDEM1: (0.014121124031007752, False)
CHRND: (0.014121124031007752, False)
RBL1: (0.014121124031007752, False)
STX1A: (0.014121124031007752, False)
AP2A2: (0.014121124031007752, False)
S100A11: (0.014121124031007752, False)
USP22: (0.014121124031007752, False)
BLNK: (0.014060562015503876, False)
TXN1: (0.014060562015503876, False)
PAFAH1B1: (0.014060562015503876, False)
HNRNPH1: (0.013998546511627907, False)
ATAD1: (0.013936531007751938, False)
RPL22: (0.013877422480620155, False)
RPGRIP1L: (0.01387451550387597, False)
ZFP42: (0.013695736434108527, False)
CTBP1: (0.013695736434108527, False)
ADD1: (0.01363517441860465, False)
NAB2: (0.013391472868217055, False)
USP9X: (0.013332364341085272, False)
MYBBP1A: (0.013271802325581396, False)
RUVBL2: (0.01321124031007752, False)
TAX1BP1: (0.013090116279069768, False)
ACTN1: (0.013029554263565892, False)
WDFY4: (0.013025193798449613, False)
DBN1: (0.012968992248062016, True)
PSMC5: (0.012905523255813954, False)
NUCB1: (0.012847868217054264, False)
KAT2B: (0.012847868217054264, False)
SSTR3: (0.012785852713178295, True)
CEP290: (0.012785852713178295, False)
GNAI2: (0.012726744186046511, False)
OTUB1: (0.012726744186046511, False)
ANXA2: (0.012666182170542635, False)
BATF3: (0.01260562015503876, False)
CORO1A: (0.012545058139534883, False)
RPL5: (0.012481589147286823, False)
SMARCD3: (0.012423934108527133, False)
RUVBL1: (0.012363372093023257, False)
MAP1S: (0.012363372093023257, False)
SULF1: (0.012363372093023257, False)
TLE1: (0.012363372093023257, False)
FXR1: (0.012361918604651162, False)
SLC11A1: (0.012242248062015505, False)
SH3GL2: (0.012242248062015505, False)
CAMK2B: (0.012242248062015505, False)
CANX: (0.012237887596899224, False)
KHSRP: (0.012180232558139535, False)
ARHGAP1: (0.012121124031007752, True)
CSNK1E: (0.012121124031007752, True)
TUFM: (0.012121124031007752, False)
DDX6: (0.012121124031007752, False)
RTN1: (0.012121124031007752, False)
GPD2: (0.012121124031007752, False)
PRKCSH: (0.012121124031007752, False)
AMOT: (0.012121124031007752, False)
UBE2E3: (0.012121124031007752, False)
DOCK10: (0.012060562015503876, False)
RUBCN: (0.012060562015503876, False)
HDGF: (0.012060562015503876, False)
KDM2B: (0.012060562015503876, False)
GDI2: (0.012056201550387597, False)
UBA52: (0.011937984496124031, False)
LDB1: (0.011871608527131783, False)
ANP32B: (0.011574612403100775, False)
LDB2: (0.011574612403100775, False)
RAB5A: (0.011453488372093024, False)
PSMD11: (0.011453488372093024, False)
PSMD2: (0.011453488372093024, False)
HINT1: (0.011392926356589148, False)
CTNND1: (0.011392926356589148, False)
RNF2: (0.011391472868217054, False)
BTRC: (0.011332364341085272, False)
SLC6A1: (0.011332364341085272, False)
CALM2: (0.011329457364341086, False)
CKAP5: (0.011328003875968991, False)
GNAI3: (0.01121124031007752, False)
NPHP1: (0.011146317829457363, False)
RPL22L1: (0.01090843023255814, False)
RNF7: (0.010906976744186047, False)
LCP1: (0.010847868217054264, False)
PAICS: (0.010787306201550387, False)
UFD1: (0.010726744186046511, False)
IQCB1: (0.010719476744186046, False)
GDI1: (0.010666182170542635, False)
RPS7: (0.010664728682170542, False)
SAFB: (0.010664728682170542, False)
CSNK2B: (0.01066327519379845, False)
CNOT3: (0.01060562015503876, False)
CALU: (0.010545058139534883, False)
HNRNPAB: (0.010543604651162792, False)
HNRNPL: (0.010484496124031007, False)
UGDH: (0.010484496124031007, False)
RPL10: (0.010423934108527133, False)
AP2B1: (0.010423934108527133, False)
UCHL5: (0.010421027131782945, False)
UCHL3: (0.010363372093023257, False)
PSMD14: (0.010363372093023257, False)
SIX6: (0.010363372093023257, False)
HSPH1: (0.010363372093023257, False)
CYFIP2: (0.010361918604651164, False)
RO60: (0.01030281007751938, False)
MBD3: (0.010242248062015505, False)
ERC1: (0.010242248062015505, False)
PTPN5: (0.010242248062015505, False)
ECSIT: (0.010242248062015505, False)
TRRAP: (0.010242248062015505, False)
CPEB1: (0.010242248062015505, False)
CSNK1A1: (0.010180232558139535, False)
MYSM1: (0.010121124031007752, False)
UBR1: (0.010121124031007752, False)
NHERF1: (0.010121124031007752, False)
RBM8A: (0.010121124031007752, False)
ACP1: (0.010121124031007752, False)
PKNOX1: (0.010121124031007752, False)
TAB2: (0.010121124031007752, False)
SCO1: (0.010121124031007752, False)
SCNN1B: (0.010121124031007752, False)
RAB5C: (0.010121124031007752, False)
RANBP1: (0.010121124031007752, False)
LIMA1: (0.010121124031007752, False)
PTMA: (0.010121124031007752, False)
CAMK2G: (0.010121124031007752, False)
ANP32A: (0.010121124031007752, False)
EIF4G2: (0.010060562015503876, False)
GPM6A: (0.010060562015503876, False)
PPP2R2A: (0.010060562015503876, False)
CAMKV: (0.010060562015503876, False)
PDCD6IP: (0.010060562015503876, False)
DNAJB6: (0.010060562015503876, False)
GGA1: (0.010060562015503876, False)
TUBA1A: (0.010059108527131783, False)
DNAJC10: (0.009877422480620155, False)
ACTR2: (0.009877422480620155, False)
CNOT7: (0.009815406976744186, False)
RPL13: (0.009756298449612403, False)
LIMS1: (0.009630813953488372, False)
LMO2: (0.009574612403100775, False)
EIF3A: (0.009514050387596899, False)
RPN2: (0.009453488372093023, False)
RPL30: (0.009449127906976745, False)
EIF2S1: (0.009391472868217055, False)
RPS20: (0.009330910852713179, False)
SYNCRIP: (0.009271802325581396, False)
PSMA1: (0.009271802325581396, False)
CUL4B: (0.009270348837209303, False)
TRIM27: (0.009150678294573644, False)
RPN1: (0.009150678294573644, False)
RBM25: (0.009150678294573644, False)
RPL4: (0.009150678294573644, False)
UBE2I: (0.009149224806201551, True)
LHX9: (0.009090116279069768, False)
CORO1C: (0.009090116279069768, False)
DYNC1I1: (0.009090116279069768, False)
FZR1: (0.009087209302325582, False)
EIF4A1: (0.008968992248062016, False)
TXNL1: (0.008968992248062016, False)
HSPE1: (0.008847868217054264, False)
HERC2: (0.008847868217054264, False)
H2BC3: (0.008843507751937985, False)
MTA2: (0.008785852713178294, False)
EIF4B: (0.008726744186046511, False)
SEC13: (0.008726744186046511, False)
RPSA: (0.008726744186046511, False)
RER1: (0.008726744186046511, False)
RANBP9: (0.008726744186046511, False)
ERCC3: (0.008664728682170542, True)
GTPBP4: (0.008661821705426356, False)
KPNB1: (0.00860562015503876, False)
EIF3F: (0.00860562015503876, False)
CAPZA2: (0.00860562015503876, False)
SNRPB: (0.00860562015503876, False)
EIF4H: (0.00860562015503876, False)
SRPK2: (0.00860562015503876, False)
CTNNA1: (0.008604166666666666, False)
PCSK2: (0.008604166666666666, False)
COX6B1: (0.008604166666666666, False)
PACSIN1: (0.008545058139534883, False)
GANAB: (0.008545058139534883, False)
NUDC: (0.008545058139534883, False)
GTF2I: (0.008484496124031009, False)
ABRAXAS2: (0.008478682170542635, False)
PGAM2: (0.008423934108527133, False)
MYO18A: (0.008423934108527133, False)
RANGAP1: (0.008423934108527133, False)
PSMC2: (0.008423934108527133, False)
SUCLA2: (0.008363372093023257, False)
LNX1: (0.008296996124031009, False)
ARHGAP26: (0.008242248062015504, False)
UBE2V1: (0.008242248062015504, False)
RPL26: (0.008242248062015504, False)
HNRNPA3: (0.008242248062015504, False)
CAVIN2: (0.008242248062015504, False)
NEFM: (0.008242248062015504, False)
IQSEC1: (0.008242248062015504, False)
DNAJA1: (0.008242248062015504, False)
UBE2D3: (0.008242248062015504, False)
RLIM: (0.008242248062015504, False)
WDFY3: (0.008242248062015504, False)
NDUFA12: (0.008242248062015504, False)
ALDH7A1: (0.008242248062015504, False)
RPS18: (0.008181686046511628, False)
UBE2O: (0.008181686046511628, False)
SYT2: (0.008181686046511628, False)
PSMC3: (0.008178779069767442, False)
TPM3: (0.008121124031007752, False)
SRSF7: (0.008121124031007752, False)
FBXO3: (0.008121124031007752, False)
ELP3: (0.008121124031007752, False)
PSPC1: (0.008121124031007752, False)
PCLO: (0.008121124031007752, False)
CTNNA2: (0.008121124031007752, False)
KCTD12: (0.008121124031007752, False)
SIN3B: (0.008121124031007752, False)
DHX36: (0.008121124031007752, False)
MAP4: (0.008121124031007752, False)
USP2: (0.008121124031007752, False)
FKBP4: (0.008121124031007752, False)
GSPT1: (0.008121124031007752, False)
U2AF2: (0.008121124031007752, False)
NMT1: (0.008121124031007752, False)
STAU1: (0.008121124031007752, False)
RPL11: (0.008121124031007752, False)
HOXA6: (0.008121124031007752, False)
BARX2: (0.008121124031007752, False)
CAPZA1: (0.008121124031007752, False)
PFKM: (0.008121124031007752, False)
SRRM2: (0.008118217054263566, False)
PSMC1: (0.008060562015503876, False)
SH3BP2: (0.008060562015503876, False)
RPL23: (0.008060562015503876, False)
RCC2: (0.008060562015503876, False)
SMARCC1: (0.008059108527131783, False)
EIF3E: (0.00805765503875969, False)
RPL24: (0.00805765503875969, False)
ASAP1: (0.007998546511627907, False)
RAVER1: (0.007933624031007752, False)
DNAJB11: (0.007874515503875969, False)
AARS1: (0.007695736434108527, False)
SLC25A5: (0.007635174418604652, False)
GNAO1: (0.007573158914728682, False)
STK26: (0.007449127906976744, False)
EIF3G: (0.007392926356589147, False)
RPL18: (0.007332364341085271, False)
TUBA1B: (0.007332364341085271, False)
HNRNPA0: (0.007271802325581396, False)
MYCBP2: (0.007268895348837209, False)
RPL6: (0.007268895348837209, False)
RPS14: (0.00721124031007752, False)
PTPRF: (0.00721124031007752, False)
UQCRH: (0.00721124031007752, False)
CYFIP1: (0.007209786821705427, False)
PRRT2: (0.007147771317829457, False)
GTF2F2: (0.007147771317829457, False)
SND1: (0.007090116279069768, False)
CNN3: (0.007029554263565892, False)
PLAA: (0.006968992248062016, False)
COX6C: (0.006968992248062016, False)
NDFIP1: (0.006967538759689923, False)
ATP5F1C: (0.00696608527131783, False)
CCT3: (0.0069084302325581395, False)
CAPZB: (0.0069084302325581395, False)
TUBB4B: (0.0068478682170542635, False)
VIRMA: (0.0068478682170542635, False)
AP2A1: (0.0068478682170542635, False)
EIF2S2: (0.006787306201550387, False)
CAPNS1: (0.006787306201550387, False)
MARK2: (0.006726744186046511, False)
ARHGDIA: (0.006726744186046511, False)
VCPIP1: (0.006726744186046511, False)
PSMD4: (0.006666182170542636, False)
TPD52L2: (0.006663275193798449, False)
CSNK2A2: (0.00660562015503876, False)
GTF2B: (0.006602713178294574, False)
HOXB8: (0.006484496124031008, False)
EIF2B5: (0.006484496124031008, False)
SLC25A3: (0.006484496124031008, False)
ILF2: (0.006484496124031008, False)
PTPRK: (0.006484496124031008, False)
PSMD13: (0.006484496124031008, False)
PPP1CB: (0.006484496124031008, False)
RPS19BP1: (0.006423934108527132, False)
SH3KBP1: (0.006423934108527132, False)
MAGI1: (0.006423934108527132, False)
RPS27: (0.006363372093023256, False)
TUBB6: (0.006363372093023256, False)
ERP44: (0.006363372093023256, False)
PSMB6: (0.006363372093023256, False)
DBNL: (0.006363372093023256, False)
TRIM56: (0.0063013565891472875, False)
OTUD4: (0.006242248062015504, False)
NCOA3: (0.006242248062015504, False)
UBA5: (0.006242248062015504, False)
BABAM2: (0.006242248062015504, False)
PGRMC2: (0.006242248062015504, False)
IDH3A: (0.006242248062015504, False)
UBQLN4: (0.006242248062015504, False)
PSMG1: (0.006181686046511628, False)
NAE1: (0.006181686046511628, False)
ARF4: (0.006181686046511628, False)
DZIP3: (0.006181686046511628, False)
PSMA4: (0.006181686046511628, False)
TUBG1: (0.006121124031007752, False)
ZPR1: (0.006121124031007752, False)
RNF114: (0.006121124031007752, False)
FBXO2: (0.006121124031007752, False)
RPS26: (0.006121124031007752, False)
NME2: (0.006121124031007752, False)
IRAK2: (0.006121124031007752, False)
NDUFS5: (0.006121124031007752, False)
NCK2: (0.006121124031007752, False)
PIAS3: (0.006121124031007752, False)
TXNDC5: (0.006121124031007752, False)
PI4KB: (0.006121124031007752, False)
VRK3: (0.006121124031007752, False)
EPB41L4A: (0.006121124031007752, False)
NEK7: (0.006121124031007752, False)
AFDN: (0.006121124031007752, False)
MGST3: (0.006121124031007752, False)
PEX6: (0.006121124031007752, False)
VTI1A: (0.006121124031007752, False)
CNOT1: (0.006121124031007752, False)
ARHGAP24: (0.006121124031007752, False)
RPS17: (0.0061167635658914725, False)
RBM39: (0.006060562015503876, False)
VPS26B: (0.006060562015503876, False)
SNX1: (0.006060562015503876, False)
ATXN2L: (0.006060562015503876, False)
PSMD1: (0.006059108527131783, False)
ATP5MK: (0.006056201550387597, False)
RPL31: (0.005937984496124031, False)
TNK2: (0.005877422480620155, False)
GPI1: (0.005877422480620155, False)
AP2S1: (0.005695736434108527, False)
ARPC1B: (0.005695736434108527, False)
RPL19: (0.005694282945736434, False)
BLMH: (0.0056351744186046515, False)
MOV10: (0.005633720930232558, False)
LARS1: (0.0055746124031007755, False)
PSMB1: (0.0055746124031007755, False)
METTL21E: (0.0055717054263565895, False)
OXSR1: (0.005514050387596899, False)
ARHGEF2: (0.005453488372093023, False)
PPP1CC: (0.005392926356589147, False)
EEF1D: (0.005332364341085271, False)
EFTUD2: (0.005332364341085271, False)
EIF5A2: (0.005271802325581396, True)
COPS3: (0.005271802325581396, False)
HBA-A1: (0.00521124031007752, False)
CAND1: (0.00521124031007752, False)
PJA2: (0.005150678294573644, False)
UBE2G2: (0.005150678294573644, False)
UHRF2: (0.005090116279069768, False)
BFAR: (0.005090116279069768, False)
BTF3: (0.005090116279069768, False)
RPS10: (0.005090116279069768, False)
STK38: (0.005090116279069768, False)
SRRT: (0.005090116279069768, False)
PDE4DIP: (0.005088662790697675, False)
RRBP1: (0.005029554263565892, False)
CHAF1A: (0.005028100775193799, False)
SDCBP: (0.004968992248062016, False)
EP400: (0.004968992248062016, False)
MYO1C: (0.004968992248062016, False)
RPL35: (0.0049084302325581395, False)
RPL3: (0.0049084302325581395, False)
SRA1: (0.004847868217054263, False)
SGTA: (0.004847868217054263, False)
RPL12: (0.004787306201550387, False)
DDX1: (0.004787306201550387, False)
VPS4B: (0.004785852713178294, False)
CCT2: (0.004726744186046511, False)
ARF3: (0.004726744186046511, False)
PTPRS: (0.004725290697674418, False)
RBM14: (0.004666182170542636, False)
MKS1: (0.004666182170542636, False)
EEF1B2: (0.00460562015503876, False)
ADRM1: (0.00460562015503876, False)
ARHGEF7: (0.00460562015503876, False)
CITED4: (0.00460562015503876, False)
CUL5: (0.00460562015503876, False)
AAK1: (0.00460562015503876, False)
SLC25A11: (0.00460562015503876, False)
DOHH: (0.004545058139534884, False)
CAPRIN1: (0.004545058139534884, False)
SNRPD1: (0.004545058139534884, False)
PFN2: (0.004545058139534884, False)
EIF3C: (0.004543604651162791, False)
RPL8: (0.004484496124031008, False)
RPL7: (0.004484496124031008, False)
EIF3L: (0.004484496124031008, False)
NDUFB6: (0.004484496124031008, False)
RBMXL1: (0.004484496124031008, False)
PLA2G15: (0.004484496124031008, False)
RNF14: (0.004484496124031008, False)
MIB2: (0.004484496124031008, False)
LEO1: (0.004484496124031008, False)
SF3A1: (0.004484496124031008, False)
DYNC1LI1: (0.004483042635658915, False)
WDR76: (0.004423934108527132, False)
PSMD12: (0.004423934108527132, False)
SERBP1: (0.004422480620155039, False)
ETFB: (0.004363372093023256, False)
ATP6V1G1: (0.004363372093023256, False)
RPS24: (0.004363372093023256, False)
PSMC4: (0.004363372093023256, False)
RPS19: (0.00430281007751938, False)
RPS25: (0.00430281007751938, False)
SRGAP2: (0.00430281007751938, False)
SNRNP70: (0.00430281007751938, False)
ADD2: (0.00430281007751938, False)
NR0B2: (0.004242248062015504, False)
DCTN3: (0.004242248062015504, False)
ECHS1: (0.004242248062015504, False)
TBL2: (0.004242248062015504, False)
SEPTIN9: (0.004242248062015504, False)
SPEN: (0.004242248062015504, False)
RAPSN: (0.004242248062015504, False)
FBXW11: (0.004242248062015504, False)
ARPC1A: (0.004242248062015504, False)
NDUFV3: (0.004242248062015504, False)
RPS21: (0.004242248062015504, False)
LIN7C: (0.004242248062015504, False)
PLEKHG5: (0.004242248062015504, False)
NCKAP1: (0.004242248062015504, False)
APMAP: (0.0042393410852713176, False)
DPY30: (0.004181686046511628, False)
COPB2: (0.004181686046511628, False)
SH3GLB2: (0.004181686046511628, False)
CDS2: (0.004181686046511628, False)
AHI1: (0.004181686046511628, False)
ZRANB1: (0.004121124031007752, False)
ZFP148: (0.004121124031007752, False)
APIP: (0.004121124031007752, False)
USP46: (0.004121124031007752, False)
TMEM165: (0.004121124031007752, False)
PITPNM1: (0.004121124031007752, False)
ARHGDIB: (0.004121124031007752, False)
HPCAL1: (0.004121124031007752, False)
CSE1L: (0.004121124031007752, False)
PTPRE: (0.004121124031007752, False)
RCN1: (0.004121124031007752, False)
SSBP3: (0.004121124031007752, False)
AARS2: (0.004121124031007752, False)
CHMP2A: (0.004121124031007752, False)
PPIB: (0.004121124031007752, False)
TBC1D5: (0.004121124031007752, False)
CRKL: (0.004121124031007752, False)
WASF1: (0.004121124031007752, False)
CTNND2: (0.004121124031007752, False)
DMRTC2: (0.004121124031007752, False)
ATP6V1C1: (0.004121124031007752, False)
NCDN: (0.004121124031007752, False)
ENDOD1: (0.004121124031007752, False)
MARK1: (0.004121124031007752, False)
ATXN10: (0.004121124031007752, False)
PSMC6: (0.004121124031007752, False)
NDEL1: (0.004121124031007752, False)
ARFGAP1: (0.004121124031007752, False)
NCEH1: (0.004121124031007752, False)
TRIOBP: (0.004121124031007752, False)
CDC73: (0.004121124031007752, False)
WASHC5: (0.004121124031007752, False)
ATP5PF: (0.004121124031007752, False)
TCEA1: (0.004121124031007752, False)
SNAPIN: (0.004121124031007752, False)
RAB14: (0.004121124031007752, False)
VAMP1: (0.004121124031007752, False)
ATP6V1H: (0.004121124031007752, False)
POLR1A: (0.004121124031007752, False)
TALDO1: (0.004121124031007752, False)
PA2G4: (0.004060562015503876, False)
NDUFA5: (0.004060562015503876, False)
AK5: (0.004060562015503876, False)
DNAJA3: (0.004060562015503876, False)
GAS7: (0.004060562015503876, False)
SEPTIN7: (0.004060562015503876, False)
PKP4: (0.0037562984496124032, False)
RAI14: (0.003695736434108527, False)
ZFP219: (0.0036351744186046515, False)
UGGT1: (0.0036351744186046515, False)
EIF3H: (0.0035746124031007754, False)
FLOT2: (0.0035746124031007754, False)
HNRNPH2: (0.0035746124031007754, False)
SIAH1A: (0.0035746124031007754, False)
ACTR3: (0.003573158914728682, False)
MCTS1: (0.0035140503875968994, False)
DPP7: (0.0035140503875968994, False)
TEDC2: (0.0035140503875968994, False)
RPL15: (0.0034534883720930233, False)
RPL28: (0.0034534883720930233, False)
EIF3B: (0.003392926356589147, False)
GNB1: (0.003392926356589147, False)
WDR1: (0.003332364341085271, False)
TUBB4A: (0.0032718023255813955, False)
HYOU1: (0.0032718023255813955, False)
EIF3I: (0.0032718023255813955, False)
STK24: (0.0032112403100775194, False)
ZMYM2: (0.0032112403100775194, False)
SPTAN1: (0.0031492248062015503, False)
RAB18: (0.0030901162790697677, False)
TLX3: (0.0030901162790697677, False)
CTPS1: (0.0030901162790697677, False)
RPL18A: (0.0030901162790697677, False)
YWHAG: (0.0030901162790697677, False)
RPL27A: (0.0030295542635658916, False)
SRGAP1: (0.0029689922480620155, False)
CLASP2: (0.0029689922480620155, False)
H3F3A: (0.0029689922480620155, False)
MITD1: (0.0029689922480620155, False)
RNF19A: (0.0029689922480620155, False)
TAF6: (0.0029084302325581395, False)
RNF31: (0.0028478682170542634, False)
SARNP: (0.0028478682170542634, False)
YWHAH: (0.0027873062015503877, False)
DCTN2: (0.0027873062015503877, False)
SARS1: (0.0027267441860465117, False)
GTF2A1: (0.0027267441860465117, False)
SEPTIN3: (0.0027267441860465117, False)
TNFAIP8: (0.0027267441860465117, False)
ING3: (0.0027267441860465117, False)
ASAP2: (0.0027267441860465117, False)
DIP2B: (0.0027267441860465117, False)
PRKAR1B: (0.0027267441860465117, False)
ASH2L: (0.0026661821705426356, False)
LNPK: (0.00260562015503876, False)
RPS28: (0.00260562015503876, False)
IPO9: (0.00260562015503876, False)
PALS2: (0.00260562015503876, False)
EHD4: (0.00260562015503876, False)
FAF2: (0.002545058139534884, False)
CLTB: (0.002545058139534884, False)
TWF2: (0.002545058139534884, False)
ZFP28: (0.002543604651162791, False)
INTS6: (0.002484496124031008, False)
RNF181: (0.002484496124031008, False)
ANKRD2: (0.002484496124031008, False)
ARL6IP1: (0.002484496124031008, False)
MED16: (0.002484496124031008, False)
DCUN1D1: (0.002484496124031008, False)
AGO3: (0.002484496124031008, False)
ARHGAP32: (0.002484496124031008, False)
RPS4X: (0.002484496124031008, False)
ACTL6A: (0.002484496124031008, False)
ARPC5: (0.0024239341085271317, False)
OTUD7B: (0.0023633720930232556, False)
SRP14: (0.0023633720930232556, False)
MAT2B: (0.0023633720930232556, False)
TMOD2: (0.0023633720930232556, False)
ATP5PO: (0.0023633720930232556, False)
RCSD1: (0.0023633720930232556, False)
PSMA6: (0.0023633720930232556, False)
HSPBP1: (0.0023633720930232556, False)
ATP5ME: (0.0023633720930232556, False)
MAN2B1: (0.0023633720930232556, False)
COPB1: (0.0023633720930232556, False)
IFI202B: (0.0023633720930232556, False)
WARS1: (0.0023633720930232556, False)
RPP30: (0.00230281007751938, False)
SPPL2A: (0.00230281007751938, False)
SEMA4A: (0.00230281007751938, False)
RPLP2: (0.00230281007751938, False)
TUBB5: (0.00230281007751938, False)
ATP5PD: (0.00230281007751938, False)
NDUFA3: (0.00230281007751938, False)
KSR1: (0.002242248062015504, False)
RPLP1: (0.002242248062015504, False)
ABT1: (0.002242248062015504, False)
DHX8: (0.002242248062015504, False)
COA7: (0.002242248062015504, False)
EPB41L1: (0.002242248062015504, False)
SEPTIN2: (0.002242248062015504, False)
ATP5MG: (0.002242248062015504, False)
PTPN13: (0.002242248062015504, False)
POLR2D: (0.002242248062015504, False)
GTF2E2: (0.002242248062015504, False)
SLC39A7: (0.002242248062015504, False)
COPZ1: (0.002242248062015504, False)
NIPSNAP1: (0.002242248062015504, False)
ARPC3: (0.002242248062015504, False)
LSM14A: (0.002242248062015504, False)
RPS16: (0.002240794573643411, False)
RPL38: (0.002240794573643411, False)
RNF11: (0.002181686046511628, False)
RPL7A: (0.002181686046511628, False)
AP3D1: (0.002181686046511628, False)
IGBP1: (0.002181686046511628, False)
DYNC1I2: (0.002181686046511628, False)
ANP32E: (0.002181686046511628, False)
PSMB2: (0.002181686046511628, False)
ATP5PB: (0.002181686046511628, False)
IMPDH1: (0.002181686046511628, False)
VTA1: (0.002181686046511628, False)
PACS1: (0.002181686046511628, False)
TSNAX: (0.002181686046511628, False)
RPS11: (0.002121124031007752, False)
CLASP1: (0.002121124031007752, False)
HECTD4: (0.002121124031007752, False)
THOC2: (0.002121124031007752, False)
HARS2: (0.002121124031007752, False)
PLPBP: (0.002121124031007752, False)
CALM3: (0.002121124031007752, False)
CSDC2: (0.002121124031007752, False)
ERO1A: (0.002121124031007752, False)
XPNPEP1: (0.002121124031007752, False)
COX6A1: (0.002121124031007752, False)
KRT13: (0.002121124031007752, False)
RFXANK: (0.002121124031007752, False)
STAM2: (0.002121124031007752, False)
ZFAND2A: (0.002121124031007752, False)
RRP9: (0.002121124031007752, False)
TLE6: (0.002121124031007752, False)
GPS1: (0.002121124031007752, False)
TAF13: (0.002121124031007752, False)
CEP170: (0.002121124031007752, False)
SCHIP1: (0.002121124031007752, False)
SEPSECS: (0.002121124031007752, False)
RPS5: (0.002121124031007752, False)
DDX17: (0.002121124031007752, False)
FKBPL: (0.002121124031007752, False)
HCLS1: (0.002121124031007752, False)
NEURL2: (0.002121124031007752, False)
HOXD3: (0.002121124031007752, False)
SNX2: (0.002121124031007752, False)
NACC1: (0.002121124031007752, False)
KRT4: (0.002121124031007752, False)
SURF6: (0.002121124031007752, False)
CHMP3: (0.002121124031007752, False)
HOMER3: (0.002121124031007752, False)
SLC25A17: (0.002121124031007752, False)
TPD52: (0.002121124031007752, False)
VBP1: (0.002121124031007752, False)
PSMD8: (0.002121124031007752, False)
ELOB: (0.002121124031007752, False)
UBA3: (0.002121124031007752, False)
RIN1: (0.002121124031007752, False)
TIMM44: (0.002121124031007752, False)
PRDM5: (0.002121124031007752, False)
KCNAB2: (0.002060562015503876, False)
ANAPC2: (0.002060562015503876, False)
RPS6KA5: (0.002060562015503876, False)
OPHN1: (0.002060562015503876, False)
LRRC8B: (0.002060562015503876, False)
PACSIN3: (0.002060562015503876, False)
ATP6V1G2: (0.002060562015503876, False)
GOLGA2: (0.002060562015503876, False)
CSDE1: (0.002060562015503876, False)
HABP4: (0.002060562015503876, False)
SLC25A22: (0.002060562015503876, False)
PAWR: (0.002060562015503876, False)
ATP8A1: (0.002060562015503876, False)
SAP18: (0.002059108527131783, False)
SFR1: (0.001937984496124031, False)
IGSF8: (0.001695736434108527, False)
RPS13: (0.001695736434108527, False)
ATP5IF1: (0.0015746124031007752, False)
AP2M1: (0.0015140503875968993, False)
CHMP5: (0.0013929263565891474, False)
NDUFB10: (0.0012718023255813954, False)
RPS8: (0.0012718023255813954, False)
UBOX5: (0.0011506782945736435, False)
UBAC2: (0.0010295542635658916, False)
NSFL1C: (0.0010295542635658916, False)
TLE4: (0.0009689922480620155, False)
NPTN: (0.0009084302325581395, False)
NCOA5: (0.0007873062015503876, False)
ARHGEF1: (0.0007873062015503876, False)
ACTBL2: (0.0007267441860465116, False)
LEPROTL1: (0.0007267441860465116, False)
SKIC8: (0.0007267441860465116, False)
FNBP1: (0.0007267441860465116, False)
ATP5F1D: (0.0007267441860465116, False)
RPL14: (0.0006661821705426356, False)
TRIM35: (0.0006661821705426356, False)
TRMT1L: (0.0006661821705426356, False)
DYNC1LI2: (0.0006056201550387597, False)
MRPL58: (0.0006056201550387597, False)
SEPTIN6: (0.0006056201550387597, False)
COPS2: (0.0005450581395348837, False)
CIBAR1: (0.00048449612403100775, False)
NHSL1: (0.00048449612403100775, False)
SMARCE1: (0.00048449612403100775, False)
GTF2F1: (0.00048449612403100775, False)
UBP1: (0.00048449612403100775, False)
HOMER2: (0.00048449612403100775, False)
EEF1G: (0.00048449612403100775, False)
FBXL16: (0.00048449612403100775, False)
H1F5: (0.00048449612403100775, False)
RPL23A: (0.00048449612403100775, False)
MTPN: (0.00048449612403100775, False)
DNAJC1: (0.0004239341085271318, False)
SNRPA: (0.0004239341085271318, False)
COXFA4: (0.0004239341085271318, False)
PDXK: (0.0004239341085271318, False)
UBXN7: (0.0003633720930232558, False)
RNF138: (0.0003633720930232558, False)
PPFIA3: (0.0003633720930232558, False)
RFX4: (0.0003633720930232558, False)
UBFD1: (0.0003633720930232558, False)
EPOP: (0.0003633720930232558, False)
H2AC21: (0.0003633720930232558, False)
H2AC20: (0.0003633720930232558, False)
RNH1: (0.0003633720930232558, False)
BLZF1: (0.0003633720930232558, False)
LNX2: (0.0003633720930232558, False)
BCL7C: (0.0003633720930232558, False)
SALL3: (0.00030281007751937984, False)
PPP5C: (0.00030281007751937984, False)
CCT5: (0.00030281007751937984, False)
PRUNE1: (0.00030281007751937984, False)
NOP16: (0.00030281007751937984, False)
PYM1: (0.00024224806201550387, False)
PDE12: (0.00024224806201550387, False)
STRN3: (0.00024224806201550387, False)
MOB4: (0.00024224806201550387, False)
SRRM1: (0.00024224806201550387, False)
NOL9: (0.00024224806201550387, False)
ZFP292: (0.00024224806201550387, False)
PHF20: (0.00024224806201550387, False)
1110004F10RIK: (0.00024224806201550387, False)
ETL4: (0.00024224806201550387, False)
RPS3A1: (0.00024224806201550387, False)
EIF3M: (0.00024224806201550387, False)
HDGFL3: (0.00024224806201550387, False)
DHRS4: (0.00024224806201550387, False)
UBXN6: (0.00024224806201550387, False)
PHLDB1: (0.00024224806201550387, False)
GATAD2B: (0.00024224806201550387, False)
AP1B1: (0.00024224806201550387, False)
AEBP2: (0.00024224806201550387, False)
SF3B2: (0.00024224806201550387, False)
TAPT1: (0.00024224806201550387, False)
SERPINA1C: (0.00024224806201550387, False)
PPP1R2: (0.00024224806201550387, False)
TTC23: (0.00024224806201550387, False)
THRAP3: (0.00024224806201550387, False)
RASAL1: (0.00024224806201550387, False)
COPS7A: (0.00024224806201550387, False)
RARS1: (0.0001816860465116279, False)
DYNLRB1: (0.0001816860465116279, False)
DHX15: (0.0001816860465116279, False)
AP1G1: (0.0001816860465116279, False)
EIF3J1: (0.0001816860465116279, False)
FBXO43: (0.0001816860465116279, False)
ANKFY1: (0.00012112403100775194, False)
POLR3F: (0.00012112403100775194, False)
NOP58: (0.00012112403100775194, False)
FASTKD5: (0.00012112403100775194, False)
RAB33B: (0.00012112403100775194, False)
CTPS2: (0.00012112403100775194, False)
UHMK1: (0.00012112403100775194, False)
RNF125: (0.00012112403100775194, False)
DHX29: (0.00012112403100775194, False)
PHF20L1: (0.00012112403100775194, False)
LRRC47: (0.00012112403100775194, False)
TUBGCP2: (0.00012112403100775194, False)
PECR: (0.00012112403100775194, False)
OTUD5: (0.00012112403100775194, False)
SPATA24: (0.00012112403100775194, False)
RAB8B: (0.00012112403100775194, False)
STRN4: (0.00012112403100775194, False)
HTATSF1: (0.00012112403100775194, False)
ARVCF: (0.00012112403100775194, False)
GM10036: (0.00012112403100775194, False)
ANKRD17: (0.00012112403100775194, False)
SUCLG2: (0.00012112403100775194, False)
RPL10A: (0.00012112403100775194, False)
POLR2E: (0.00012112403100775194, False)
H4C14: (0.00012112403100775194, False)
SDF2L1: (0.00012112403100775194, False)
RTRAF: (0.00012112403100775194, False)
TTC4: (0.00012112403100775194, False)
CCT4: (0.00012112403100775194, False)
ARHGAP33: (0.00012112403100775194, False)
PRRC2C: (0.00012112403100775194, False)
POLR2C: (0.00012112403100775194, False)
VTI1B: (0.00012112403100775194, False)
PPP1R12C: (0.00012112403100775194, False)
IGHMBP2: (0.00012112403100775194, False)
CCT6B: (0.00012112403100775194, False)
ZFP128: (0.00012112403100775194, False)
ARFGEF3: (0.00012112403100775194, False)
ATP5MF: (0.00012112403100775194, False)
MRPL11: (0.00012112403100775194, False)
ARPC5L: (0.00012112403100775194, False)
UBE2R2: (0.00012112403100775194, False)
PCYOX1: (0.00012112403100775194, False)
EPN2: (0.00012112403100775194, False)
ELP6: (0.00012112403100775194, False)
TAB3: (0.00012112403100775194, False)
H1F1: (0.00012112403100775194, False)
KLHL17: (0.00012112403100775194, False)
PYCR3: (6.056201550387597e-05, False)
EPB41: (6.056201550387597e-05, False)
KLHL40: (6.056201550387597e-05, False)
EPB41L2: (6.056201550387597e-05, False)
COPS8: (6.056201550387597e-05, False)
CACTIN: (6.056201550387597e-05, False)
RPL27: (6.056201550387597e-05, False)
PAIP1: (6.056201550387597e-05, False)
EMG1: (6.056201550387597e-05, False)
WASHC2: (6.056201550387597e-05, False)
ATP6V1F: (6.056201550387597e-05, False)
Finally there’s the gene set enrichment analysis, which with just the enriched results (without the pubmed metric) produces mediocre results. The hybrid metric does show meaningful results. The inflammatory response is the top hit which is promising since it’s known inflammation drives aging.
Experimental-only GSEA
Hybrid metric GSEA
